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Study · Ex vivo tissue · rat · 2017

4 results

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Povarov IS, Kondratenko RV, Derevyagin VI, Myasoedov NF, Skrebitsky VG

Bulletin of experimental biology and medicine30 Mar 2017

PMID28361410 (opens in a new tab)DOI10.1007/s10517-017-3676-3 (opens in a new tab)PepBankPUB-28361410
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hippocampal slices, Selank increased the amplitude of spontaneous inhibitory postsynaptic currents in CA1 pyramidal neurons.

    In plain wordsIn rat brain slices, Selank increased the size of inhibitory signals in hippocampal neurons.

    Peptide
    Selank
    Outcome
    IncreaseAmplitude of spontaneous inhibitory postsynaptic currents
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 pyramidal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents
    1 context sentence
    Summary · context
    Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons.
  2. 02LabEx vivo tissueMechanism

    In rat hippocampal slices, Selank increased the discharge rate of spontaneous inhibitory postsynaptic currents in CA1 pyramidal neurons.

    In plain wordsIn rat brain slices, Selank increased how often inhibitory signals fired in hippocampal neurons.

    Peptide
    Selank
    Outcome
    IncreaseDischarge rate of spontaneous inhibitory postsynaptic currents
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 pyramidal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents
    1 context sentence
    Summary · context
    Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons.
  3. 03LabEx vivo tissueMechanism

    In some CA1 neurons, the Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity.

    In plain wordsIn some rat brain cells, Selank first briefly lowered inhibitory signals before they increased.

    Peptide
    Selank
    Outcome
    MixedTransient decrease before up-regulation of inhibitory currents
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 pyramidal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity.
    1 context sentence
    Summary · context
    Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons.
  4. 04LabEx vivo tissueMechanism

    Across 1-8 μM, Selank showed no significant dose-dependence in its effect on spontaneous inhibitory currents in rat hippocampal neurons.

    In plain wordsIn rat brain slices, the Selank effect did not change significantly with dose across the tested range.

    Peptide
    Selank
    Outcome
    No significant changeDose-dependence of effect on inhibitory currents
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 pyramidal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1-8 μMAs given in this study (rat).

    Source sentences

    Summary
    In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.
    1 context sentence
    Summary · context
    Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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