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Study · Not a test of the peptide alone · 2017

3 results

Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis.

Zeng M, Shao A, Li H, Tang Y, Li Q, Guo Z, Wu C, Cheng Y, Tian H, Zhu WH

ACS applied materials & interfaces7 Apr 2017Cited by 28 (Europe PMC)

PMID28349696 (opens in a new tab)DOI10.1021/acsami.7b00936 (opens in a new tab)PepBankPUB-28349696
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

  1. 01AnimalNot a test of KPV aloneAnimal study (in vivo)Other

    The DCM-KPV probe allowed noninvasive observation of accumulation in colon inflammation regions and distinguished chronic colitis, acute colitis and normal groups.

    In plain wordsIn a colitis model, a KPV-based probe made it possible to tell chronic colitis, acute colitis and normal groups apart.

    Peptide
    KPV
    Outcome
    Not applicableDiscrimination of chronic, acute colitis and normal groups by DCM-KPV imaging
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    the fluorescent probe of DCM-KPV makes a breakthrough to the direct noninvasive observation of the accumulation in colon inflammation regions via intestinal mucosa, even successfully distinguishing the chronic, acute ulcerative colitis and normal groups.
    1 context sentence
    Summary · context
    Herein, we report a PepT1 peptide receptor-targeted fluorescent probe, dicyanomethylene-4H-pyran (DCM)-KPV, with the strategy of conjugating the KPV into the DCM chromophore.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  2. 02LabNot a test of KPV aloneIn vitro (cells)Other

    In a Caco-2 cell model of ulcerative colitis with overexpressed PepT1, the DCM-KPV probe accumulated KPV in the cytoplasm and nucleus.

    In plain wordsIn cells, a KPV-based probe built up inside colon cells that carry the PepT1 transporter.

    Peptide
    KPV
    Outcome
    Not applicableDCM-KPV accumulation in PepT1-overexpressing Caco-2 cells
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    We build the overexpressed PepT1 on the cytomembrane of ulcerative colitis model Caco-2 cell as the efficient receptor to accumulate the targeted tripeptide KPV in the cytoplasm and nucleus.
    1 context sentence
    Summary · context
    Herein, we report a PepT1 peptide receptor-targeted fluorescent probe, dicyanomethylene-4H-pyran (DCM)-KPV, with the strategy of conjugating the KPV into the DCM chromophore.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  3. 03LabNot a test of KPV aloneIn vitro (cells)Safety outcome

    The DCM-KPV probe showed negligible cytotoxicity and high cytocompatibility in living cells.

    In plain wordsIn cells, the KPV-based probe caused almost no harm.

    Peptide
    KPV
    Outcome
    No significant changeCytotoxicity of DCM-KPV probe
    Study

    n: not reported in source

    Outcome group
    Adverse events · Gastrointestinal

    Source sentences

    Summary
    possessing several beneficial characteristics, such as efficient long emission, low photobleaching, negligible cytotoxicity, and high cytocompatibility in living cells.
    1 context sentence
    Summary · context
    Herein, we report a PepT1 peptide receptor-targeted fluorescent probe, dicyanomethylene-4H-pyran (DCM)-KPV, with the strategy of conjugating the KPV into the DCM chromophore.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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