Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems.

Glenn AL, Lochman JE, Dishion T, Powell NP, Boxmeyer C, Qu L

Prevention science : the official journal of the Society for Prevention Research1 Jan 2018Cited by 17 (Europe PMC)

PMID28303421PMCIDPMC5600646DOI10.1007/s11121-017-0777-1PepBankPUB-28303421

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01HumanNot a test of Oxytocin aloneRandomized controlled trialOther
In African-American children with conduct problems, outcomes of the Coping Power program depended on an interaction between OXTR rs2268493 genotype and delivery format.
In plain wordsIn children with behavior problems, how well a program worked depended on the child's oxytocin receptor gene variant and whether it was group or individual.
Peptide
Oxytocin
Outcome
Not applicableOXTR genotype by delivery format interaction on externalizing problems
Study
n = 197
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Growth curve analyses revealed a genotype by delivery format interaction.
1 context sentence(design, population, supporting numbers)
Summary · context
One variant of OXTR (rs2268493) was examined in 197 fourth-grade African-American children (64% male) who were randomly assigned to Group Coping Power or Individual Coping Power (Lochman et al. 2015).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2830342101
02HumanNot a test of Oxytocin aloneRandomized controlled trialOther
Children with the OXTR A/A genotype showed reductions in externalizing problems during the intervention regardless of format.
In plain wordsChildren with the A/A oxytocin receptor gene variant had fewer behavior problems after the program, in either group or individual format.
Peptide
Oxytocin
Outcome
DecreaseExternalizing problems in A/A genotype youth
Study
n: not reported in source
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Youth with the A/A genotype demonstrated reductions in externalizing problems over the course of the intervention regardless of intervention format.
1 context sentence(design, population, supporting numbers)
Summary · context
One variant of OXTR (rs2268493) was examined in 197 fourth-grade African-American children (64% male) who were randomly assigned to Group Coping Power or Individual Coping Power (Lochman et al. 2015).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2830342102
03HumanNot a test of Oxytocin aloneRandomized controlled trialOther
Carriers of the OXTR G allele in the group format showed little improvement during the intervention and worsening of symptoms during follow-up.
In plain wordsChildren with the G oxytocin receptor gene variant in the group program improved little and got worse during the following year.
Peptide
Oxytocin
Outcome
MixedExternalizing problems in G allele carriers, group format
Study
n: not reported in source
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
In contrast, carriers of the G allele receiving the group-based intervention showed little improvement during the intervention and a worsening of symptoms during the follow-up year
1 context sentence(design, population, supporting numbers)
Summary · context
One variant of OXTR (rs2268493) was examined in 197 fourth-grade African-American children (64% male) who were randomly assigned to Group Coping Power or Individual Coping Power (Lochman et al. 2015).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2830342103
04HumanNot a test of Oxytocin aloneRandomized controlled trialOther
Carriers of the OXTR G allele in the individual format showed reductions in externalizing problems.
In plain wordsChildren with the G oxytocin receptor gene variant in the individual program had fewer behavior problems.
Peptide
Oxytocin
Outcome
DecreaseExternalizing problems in G allele carriers, individual format
Study
n: not reported in source
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
while those receiving the individual format demonstrated reductions in externalizing problems.
1 context sentence(design, population, supporting numbers)
Summary · context
One variant of OXTR (rs2268493) was examined in 197 fourth-grade African-American children (64% male) who were randomly assigned to Group Coping Power or Individual Coping Power (Lochman et al. 2015).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2830342104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:49 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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