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Study · Randomized controlled trial · n = 52 · 2017

2 results

Oxytocin reduces amygdala responses during threat approach.

Radke S, Volman I, Kokal I, Roelofs K, de Bruijn ERA, Toni I

Psychoneuroendocrinology28 Feb 2017Cited by 54 (Europe PMC)

PMID28285187 (opens in a new tab)DOI10.1016/j.psyneuen.2017.02.028 (opens in a new tab)PepBankPUB-28285187
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy males, oxytocin decreased amygdala activation during threat approach versus placebo.

    In plain wordsIn healthy men, oxytocin lowered amygdala activity while approaching a threat, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala activation during threat approach
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin decreased amygdala activation during threat approach
    1 context sentence
    Summary · context
    The current administration study tested whether oxytocin either reduces or enhances amygdala responses during threat approach in a placebo-controlled randomized, double-blind, between-subjects design with 52 healthy males undergoing fMRI during a social approach-avoidance task.
  2. 02HumanRandomized controlled trialMechanism

    In healthy males, oxytocin did not change amygdala activation during threat avoidance versus placebo.

    In plain wordsIn healthy men, oxytocin did not change amygdala activity while avoiding a threat, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmygdala activation during threat avoidance
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin decreased amygdala activation during threat approach and not during threat avoidance.
    1 context sentence
    Summary · context
    The current administration study tested whether oxytocin either reduces or enhances amygdala responses during threat approach in a placebo-controlled randomized, double-blind, between-subjects design with 52 healthy males undergoing fMRI during a social approach-avoidance task.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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