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Study · Animal study (in vivo) · rat · 2017

4 results

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.

Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M

Behavioural neurology9 Feb 2017Cited by 6 (Europe PMC)

PMID28280289 (opens in a new tab)PMCIDPMC5322660 (opens in a new tab)DOI10.1155/2017/5091027 (opens in a new tab)PepBankPUB-28280289
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Summary

It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats without chronic stress, a course of test substances worsened anxiety indicators, and the change was less pronounced after a course of Selank.

    In plain wordsIn rats without chronic stress, anxiety indicators got worse after the test substances, but less so after Selank.

    Peptide
    Selank
    Outcome
    MixedAnxiety indicators without chronic stress
    Study

    ratn: not reported in source

    Unpredictable chronic mild stress; elevated plus maze
    Comparator
    Diazepam
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced.
    1 context sentence
    Summary · context
    To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, individual administration of Selank was the most effective in reducing elevated anxiety induced by a course of test substances.

    In plain wordsIn rats, Selank alone reduced the raised anxiety caused by the test substances better than the other treatments.

    Peptide
    Selank
    Outcome
    DecreaseReduction of anxiety raised by the test-substance course (Selank alone)
    Study

    ratn: not reported in source

    Unpredictable chronic mild stress; elevated plus maze
    Comparator
    Diazepam; diazepam plus Selank
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances
    1 context sentence
    Summary · context
    To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats under unpredictable chronic mild stress, the combination of diazepam with Selank was the most effective in reducing anxiety.

    In plain wordsIn stressed rats, diazepam and Selank together reduced anxiety more than either one alone.

    Peptide
    Selank
    Outcome
    DecreaseAnxiety under chronic mild stress (diazepam plus Selank)
    Study

    ratn: not reported in source

    Unpredictable chronic mild stress; elevated plus maze
    Comparator
    Individual diazepam or Selank
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.
    1 context sentence
    Summary · context
    To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test.

Studies that did not test the peptide alone1

In this study, Selank was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Selank.

  1. 04AnimalNot a test of Selank aloneAnimal study (in vivo)Efficacy outcome

    In rats under chronic mild stress, anxiety indicators after combined diazepam and Selank did not differ from values before chronic stress.

    In plain wordsIn stressed rats, anxiety measures after diazepam and Selank together were the same as before the stress.

    Peptide
    Selank
    Outcome
    No significant changeAnxiety indicators after Selank plus diazepam under chronic stress
    Study

    ratn: not reported in source

    Unpredictable chronic mild stress; elevated plus maze
    Comparator
    Values before chronic stress
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure.
    1 context sentence
    Summary · context
    To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test.

    In this study, Selank was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Selank.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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