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Study · Animal study (in vivo) · rat · 2017

5 results

Davunetide improves spatial learning and memory in Alzheimer's disease-associated rats.

Zhang J, Wei SY, Yuan L, Kong LL, Zhang SX, Wang ZJ, Wu MN, Qi JS

Physiology & behavior28 Feb 2017Cited by 10 (Europe PMC)

PMID28257938 (opens in a new tab)DOI10.1016/j.physbeh.2017.02.038 (opens in a new tab)PepBankPUB-28257938
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Aβ1-42-induced impairment, davunetide reversed increased escape latency in a dose-dependent manner.

    In plain wordsIn rats, davunetide reversed increased escape latency after Aβ1-42 exposure.

    Peptide
    Davunetide
    Outcome
    DecreaseEscape latency
    Study

    ratn: not reported in source

    Aβ1-42-induced cognitive impairment
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · three weeksAs given in this study (rat).

    Source sentences

    Summary
    In Morris water maze (MWM) test, bilateral intrahippocampal injection of Aβ1-42 significantly increased escape latency and decreased target quadrant swimming time of rats, while three weeks of intranasal application of davunetide reversed the Aβ1-42-induced learning deficits and memory loss in a dose-dependent manner.
    1 context sentence
    Summary · context
    To further characterize the neuroprotective roles of davunetide and its possible mechanism, the present study investigated the effects of davunetide on Aβ1-42-induced impairments in spatial memory, synaptic plasticity and hippocampal AKT level.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, davunetide reversed Aβ1-42-induced loss of target quadrant swimming time in a dose-dependent manner.

    In plain wordsIn rats, davunetide reversed reduced target quadrant swimming time after Aβ1-42 exposure.

    Peptide
    Davunetide
    Outcome
    IncreaseTarget quadrant swimming time
    Study

    ratn: not reported in source

    Aβ1-42-induced cognitive impairment
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · three weeksAs given in this study (rat).

    Source sentences

    Summary
    In Morris water maze (MWM) test, bilateral intrahippocampal injection of Aβ1-42 significantly increased escape latency and decreased target quadrant swimming time of rats, while three weeks of intranasal application of davunetide reversed the Aβ1-42-induced learning deficits and memory loss in a dose-dependent manner.
    1 context sentence
    Summary · context
    To further characterize the neuroprotective roles of davunetide and its possible mechanism, the present study investigated the effects of davunetide on Aβ1-42-induced impairments in spatial memory, synaptic plasticity and hippocampal AKT level.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, davunetide blocked Aβ1-42-induced suppression of hippocampal long-term potentiation.

    In plain wordsIn rats, davunetide blocked suppression of hippocampal long-term potentiation after Aβ1-42 exposure.

    Peptide
    Davunetide
    Outcome
    IncreaseHippocampal long-term potentiation
    Study

    ratn: not reported in source

    Aβ1-42-induced cognitive impairment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · three weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo field potentiation recording showed that Aβ1-42 suppressed long-term potentiation (LTP) of excitatory postsynaptic potential (fEPSP) in the hippocampal CA1 region of rats, while davunetide effectively blocked the suppression of LTP, without affecting paired-pulse facilitation (PPF).
    1 context sentence
    Summary · context
    To further characterize the neuroprotective roles of davunetide and its possible mechanism, the present study investigated the effects of davunetide on Aβ1-42-induced impairments in spatial memory, synaptic plasticity and hippocampal AKT level.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, davunetide did not affect paired-pulse facilitation.

    In plain wordsIn rats, davunetide did not affect paired-pulse facilitation.

    Peptide
    Davunetide
    Outcome
    No significant changePaired-pulse facilitation
    Study

    ratn: not reported in source

    Aβ1-42-induced cognitive impairment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · three weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo field potentiation recording showed that Aβ1-42 suppressed long-term potentiation (LTP) of excitatory postsynaptic potential (fEPSP) in the hippocampal CA1 region of rats, while davunetide effectively blocked the suppression of LTP, without affecting paired-pulse facilitation (PPF).
    1 context sentence
    Summary · context
    To further characterize the neuroprotective roles of davunetide and its possible mechanism, the present study investigated the effects of davunetide on Aβ1-42-induced impairments in spatial memory, synaptic plasticity and hippocampal AKT level.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, davunetide mostly antagonized the Aβ1-42-induced decrease in hippocampal p-AKT (Ser473).

    In plain wordsIn rats, davunetide largely reversed reduced hippocampal p-AKT after Aβ1-42 exposure.

    Peptide
    Davunetide
    Outcome
    IncreaseHippocampal p-AKT (Ser473)
    Study

    ratn: not reported in source

    Aβ1-42-induced cognitive impairment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · three weeksAs given in this study (rat).

    Source sentences

    Summary
    Western blotting experiments showed a significant decrease in the level of hippocampal p-AKT (Ser473), not total AKT, in Aβ1-42 only group, which was mostly antagonized by davunetide treatment.
    1 context sentence
    Summary · context
    To further characterize the neuroprotective roles of davunetide and its possible mechanism, the present study investigated the effects of davunetide on Aβ1-42-induced impairments in spatial memory, synaptic plasticity and hippocampal AKT level.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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