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Study · Animal study (in vivo) · rat · 2017

5 results

Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats.

Medvedeva EV, Dmitrieva VG, Limborska SA, Myasoedov NF, Dergunova LV

Molecular genetics and genomics : MGG2 Mar 2017Cited by 15 (Europe PMC)

PMID28255762 (opens in a new tab)DOI10.1007/s00438-017-1297-1 (opens in a new tab)PepBankPUB-28255762
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In the cerebral cortex of rats with focal cerebral ischemia, Semax enhanced the antigen presentation signaling pathway.

    In plain wordsIn rats with stroke-like brain injury, Semax strengthened an immune signaling pathway in the brain cortex.

    Peptide
    Semax
    Outcome
    IncreaseAntigen presentation signaling pathway
    Study

    ratn: not reported in source

    focal cerebral ischemia, cerebral cortex transcriptome
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax enhances antigen presentation signaling pathway
    1 context sentence
    Summary · context
    To reveal biological processes and signaling pathways, which are affected by Semax and PGP, we performed the transcriptome analysis of cerebral cortex of rats with focal cerebral ischemia treated by these peptides.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In the cerebral cortex of rats with focal cerebral ischemia, Semax intensified the effect of ischemia on the interferon signaling pathways.

    In plain wordsIn rats with stroke-like brain injury, Semax intensified the effect of the injury on interferon signaling in the brain.

    Peptide
    Semax
    Outcome
    IncreaseInterferon signaling pathways
    Study

    ratn: not reported in source

    focal cerebral ischemia, cerebral cortex transcriptome
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    intensifies the effect of ischemia on the interferon signaling pathways
    1 context sentence
    Summary · context
    To reveal biological processes and signaling pathways, which are affected by Semax and PGP, we performed the transcriptome analysis of cerebral cortex of rats with focal cerebral ischemia treated by these peptides.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In the cerebral cortex of rats with focal cerebral ischemia, Semax affected the processes for synthesizing immunoglobulins.

    In plain wordsIn rats with stroke-like brain injury, Semax affected processes that make immunoglobulins in the brain cortex.

    Peptide
    Semax
    Outcome
    Direction not reportedImmunoglobulin synthesis processes
    Study

    ratn: not reported in source

    focal cerebral ischemia, cerebral cortex transcriptome
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    affects the processes for synthesizing immunoglobulins.
    1 context sentence
    Summary · context
    To reveal biological processes and signaling pathways, which are affected by Semax and PGP, we performed the transcriptome analysis of cerebral cortex of rats with focal cerebral ischemia treated by these peptides.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In the cerebral cortex of rats with focal cerebral ischemia, Semax significantly increased expression of the gene encoding the immunoglobulin heavy chain.

    In plain wordsIn rats with stroke-like brain injury, Semax raised activity of the immunoglobulin heavy chain gene in the brain cortex.

    Peptide
    Semax
    Outcome
    IncreaseImmunoglobulin heavy chain gene expression
    Study

    ratn: not reported in source

    focal cerebral ischemia, cerebral cortex transcriptome
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax significantly increased expression of the gene encoding the immunoglobulin heavy chain
    1 context sentence
    Summary · context
    To reveal biological processes and signaling pathways, which are affected by Semax and PGP, we performed the transcriptome analysis of cerebral cortex of rats with focal cerebral ischemia treated by these peptides.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In the cerebral cortex of rats with focal cerebral ischemia, Semax strongly affected expression of cytokine, stress response and ribosomal protein-encoding genes after occlusion.

    In plain wordsIn rats with stroke-like brain injury, Semax changed activity of cytokine, stress and ribosomal protein genes in the brain cortex.

    Peptide
    Semax
    Outcome
    Direction not reportedCytokine, stress response and ribosomal protein gene expression
    Study

    ratn: not reported in source

    focal cerebral ischemia, cerebral cortex transcriptome
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    highly affects on cytokine, stress response and ribosomal protein-encoding genes after occlusion.
    1 context sentence
    Summary · context
    To reveal biological processes and signaling pathways, which are affected by Semax and PGP, we performed the transcriptome analysis of cerebral cortex of rats with focal cerebral ischemia treated by these peptides.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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