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Study · Animal study (in vivo) · rat · 2017

2 results

Ghrelin alleviates anxiety- and depression-like behaviors induced by chronic unpredictable mild stress in rodents.

Huang HJ, Zhu XC, Han QQ, Wang YL, Yue N, Wang J, Yu R, Li B, Wu GC, Liu Q, Yu J

Behavioural brain research27 Feb 2017Cited by 97 (Europe PMC)

PMID28245976 (opens in a new tab)DOI10.1016/j.bbr.2017.02.040 (opens in a new tab)PepBankPUB-28245976
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to chronic unpredictable mild stress, central GHRP‑6 significantly alleviated depression-like behavior in the forced swimming test.

    In plain wordsIn stressed rats, central GHRP‑6 reduced depression-like behavior in the forced swimming test.

    Peptide
    GHRP-6
    Outcome
    DecreaseDepression-like behavior in forced swimming test
    Study

    ratn: not reported in source

    Chronic unpredictable mild stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10μg/rat/day · intracerebroventricular · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Further results showed that central treatment of ghrelin (10μg/rat/day for 2 weeks, i.c.v.) or GHRP-6 (the agonist of GHSR, 10μg/rat/day for 2 weeks, i.c.v.) significantly alleviated the depression-like behaviors induced by CUMS in FST and sucrose preference test (SPT).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to chronic unpredictable mild stress, central GHRP‑6 significantly alleviated depression-like behavior in the sucrose preference test.

    In plain wordsIn stressed rats, central GHRP‑6 reduced depression-like behavior in the sucrose preference test.

    Peptide
    GHRP-6
    Outcome
    DecreaseDepression-like behavior in sucrose preference test
    Study

    ratn: not reported in source

    Chronic unpredictable mild stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10μg/rat/day · intracerebroventricular · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Further results showed that central treatment of ghrelin (10μg/rat/day for 2 weeks, i.c.v.) or GHRP-6 (the agonist of GHSR, 10μg/rat/day for 2 weeks, i.c.v.) significantly alleviated the depression-like behaviors induced by CUMS in FST and sucrose preference test (SPT).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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