In rats with isoproterenol-induced myocardial ischemia, cerebrolysin pretreatment significantly attenuated oxidative stress-induced myocardial apoptosis.
In plain wordsIn rats with induced heart ischemia, cerebrolysin pretreatment reduced stress-induced cell death in heart tissue.
- Peptide
- Cerebrolysin
- Outcome
- DecreaseOxidative stress-induced apoptosis
- Study
ratn: not reported in source
Isoproterenol-induced myocardial ischemia- Outcome group
- Heart function · Cardiovascular
- Studied dose
- 5 mL/kg · intraperitoneal · 7 daysAs given in this study (rat).
Source sentences
Cerebrolysin pretreatment caused significant attenuation of the oxidative stress-induced apoptosis in the ischemic myocardial tissue.
2 context sentences(design, population, supporting numbers)
This study was designed to investigate the possible effect of cerebrolysin against apoptosis triggered by oxidative cell stress in myocardial ischemia induced by isoproterenol in rat.
Rats were pretreated with cerebrolysin 5 mL/kg intraperitoneally for 7 days and intoxicated with isoproterenol (ISO, 85 mg/kg, sc) on the last 2 days.