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Study · Animal study (in vivo) · mouse · 2017

7 results

Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice.

Chang WL, Masih S, Thadi A, Patwa V, Joshi A, Cooper HS, Palejwala VA, Clapper ML, Shailubhai K

World journal of gastrointestinal pharmacology and therapeutics1 Feb 2017Cited by 23 (Europe PMC)

PMID28217374 (opens in a new tab)PMCIDPMC5292606 (opens in a new tab)DOI10.4292/wjgpt.v8.i1.47 (opens in a new tab)PepBankPUB-28217374
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In DSS-treated Apc mutant mice, plecanatide significantly reduced polypoid, flat and indeterminate dysplasia formation.

    In plain wordsIn mice with DSS-induced inflammation, plecanatide reduced polypoid, flat and indeterminate dysplasia formation.

    Peptide
    Plecanatide
    Outcome
    DecreaseDysplasia formation
    Study

    mousen: not reported in source

    Apc+/Min-FCCC mice with DSS-induced inflammation
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0-20 ppm · oralAs given in this study (mouse).

    Source sentences

    Summary
    Oral treatment of Apc+/MinFCCC mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias.
    1 context sentence
    Summary · context
    Mice were fed a diet supplemented with plecanatide (0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid, flat and indeterminate dysplasia was evaluated.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In DSS-treated Apc mutant mice, plecanatide activated cGMP/GC-C signaling.

    In plain wordsIn mice, plecanatide activated cGMP/GC-C signaling.

    Peptide
    Plecanatide
    Outcome
    IncreasecGMP/GC-C signaling
    Study

    mousen: not reported in source

    Apc+/Min-FCCC mice with DSS-induced inflammation
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    0-20 ppm · oralAs given in this study (mouse).

    Source sentences

    Summary
    This anti-carcinogenic activity of plecanatide was accompanied by activation of cGMP/GC-C signaling mediated inhibition of Wnt/β-catenin signaling and reduced proliferation.
    1 context sentence
    Summary · context
    Mice were fed a diet supplemented with plecanatide (0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid, flat and indeterminate dysplasia was evaluated.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In DSS-treated Apc mutant mice, plecanatide inhibited Wnt/β-catenin signaling.

    In plain wordsIn mice, plecanatide inhibited Wnt/β-catenin signaling.

    Peptide
    Plecanatide
    Outcome
    DecreaseWnt/β-catenin signaling
    Study

    mousen: not reported in source

    Apc+/Min-FCCC mice with DSS-induced inflammation
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    0-20 ppm · oralAs given in this study (mouse).

    Source sentences

    Summary
    This anti-carcinogenic activity of plecanatide was accompanied by activation of cGMP/GC-C signaling mediated inhibition of Wnt/β-catenin signaling and reduced proliferation.
    1 context sentence
    Summary · context
    Mice were fed a diet supplemented with plecanatide (0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid, flat and indeterminate dysplasia was evaluated.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In DSS-treated Apc mutant mice, plecanatide reduced proliferation.

    In plain wordsIn mice, plecanatide reduced proliferation.

    Peptide
    Plecanatide
    Outcome
    DecreaseProliferation
    Study

    mousen: not reported in source

    Apc+/Min-FCCC mice with DSS-induced inflammation
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0-20 ppm · oralAs given in this study (mouse).

    Source sentences

    Summary
    This anti-carcinogenic activity of plecanatide was accompanied by activation of cGMP/GC-C signaling mediated inhibition of Wnt/β-catenin signaling and reduced proliferation.
    1 context sentence
    Summary · context
    Mice were fed a diet supplemented with plecanatide (0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid, flat and indeterminate dysplasia was evaluated.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with acute DSS-induced inflammation, plecanatide decreased colon-explant secretion of cytokines (IL-6, IL1 TNF), chemokines (MIP-1, IP-10) and growth factors (GCSF and GMCSF).

    In plain wordsIn mice with DSS-induced inflammation, plecanatide decreased cytokine, chemokine and growth factor secretion measured in colon explants.

    Peptide
    Plecanatide
    Outcome
    DecreaseInflammatory mediator secretion
    Study

    mousen: not reported in source

    Apc+/Min-FCCC mice with DSS-induced inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    0-20 ppm · oralAs given in this study (mouse).

    Source sentences

    Summary
    Plecanatide also decreased secretion of pro-inflammatory cytokines (IL-6, IL1 TNF), chemokines (MIP-1, IP-10) and growth factors (GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation.
    1 context sentence
    Summary · context
    Mice were fed a diet supplemented with plecanatide (0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid, flat and indeterminate dysplasia was evaluated.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In plecanatide-treated mice, intestinal GC-C expression did not change appreciably.

    In plain wordsIn mice, intestinal GC-C expression did not change appreciably with plecanatide.

    Peptide
    Plecanatide
    Outcome
    No significant changeGC-C expression
    Study

    mousen: not reported in source

    Apc+/Min-FCCC mice with DSS-induced inflammation
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    0-20 ppm · oralAs given in this study (mouse).

    Source sentences

    Summary
    Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia.
    2 context sentences
    Summary · context
    The effect of plecanatide-mediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues.
    Summary · context
    Mice were fed a diet supplemented with plecanatide (0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid, flat and indeterminate dysplasia was evaluated.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In plecanatide-treated mice, uroguanylin transcripts increased significantly in the proximal small intestine and colon.

    In plain wordsIn mice, plecanatide increased uroguanylin transcripts in the proximal small intestine and colon.

    Peptide
    Plecanatide
    Outcome
    IncreaseUroguanylin transcripts
    Study

    mousen: not reported in source

    Apc+/Min-FCCC mice with DSS-induced inflammation
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    0-20 ppm · oralAs given in this study (mouse).

    Source sentences

    Summary
    Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia.
    2 context sentences
    Summary · context
    The effect of plecanatide-mediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues.
    Summary · context
    Mice were fed a diet supplemented with plecanatide (0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid, flat and indeterminate dysplasia was evaluated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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