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Study · Randomized controlled trial · 2017

3 results

Within vs. between-subject effects of intranasal oxytocin on the neural response to cooperative and non-cooperative social interactions.

Chen X, Gautam P, Haroon E, Rilling JK

Psychoneuroendocrinology16 Jan 2017Cited by 29 (Europe PMC)

PMID28142074 (opens in a new tab)PMCIDPMC5362337 (opens in a new tab)DOI10.1016/j.psyneuen.2017.01.006 (opens in a new tab)PepBankPUB-28142074
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In women performing a Prisoner Dilemma task, intranasal oxytocin attenuated the ventral tegmental area response to reciprocated cooperation in a within-subject design, as in the earlier cross-sectional sample.

    In plain wordsIn women playing a cooperation game, nasal oxytocin lowered the brain's reward-area response to a partner who cooperated back.

    Peptide
    Oxytocin
    Outcome
    DecreaseVentral tegmental area response to reciprocated cooperation (women)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    We found OT to attenuate the ventral tegmental area response to reciprocated cooperation in women, an effect that is also present in our cross-sectional sample.
    1 context sentence
    Summary · context
    In the current study, we investigated if the main findings from our cross-sectional study could be replicated in a within-subject design using the same paradigm and whether new findings would emerge.
  2. 02HumanRandomized controlled trialMechanism

    In the within-subject design, the other cross-sectional oxytocin findings, especially those in men, were not observed.

    In plain wordsMost earlier oxytocin brain effects, especially those in men, did not appear again in this repeated-measures study.

    Peptide
    Oxytocin
    Outcome
    No significant changeReplication of cross-sectional oxytocin findings in men
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    However, other cross-sectional findings, especially those found in men, were not observed in this within-subject study.
    1 context sentence
    Summary · context
    In the current study, we investigated if the main findings from our cross-sectional study could be replicated in a within-subject design using the same paradigm and whether new findings would emerge.
  3. 03HumanRandomized controlled trialMechanism

    In men, oxytocin on scan 2 blocked the amygdala habituation to unreciprocated cooperation that was seen in men who received placebo on both scans.

    In plain wordsIn men, oxytocin stopped the amygdala from getting used to a partner who did not cooperate back, unlike placebo.

    Peptide
    Oxytocin
    Outcome
    MixedAmygdala habituation to unreciprocated cooperation (men)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Most importantly, OT treatment on scan 2 blocked amygdala habituation to unreciprocated cooperation found in a group that received placebo on both scans among men.
    1 context sentence
    Summary · context
    In the current study, we investigated if the main findings from our cross-sectional study could be replicated in a within-subject design using the same paradigm and whether new findings would emerge.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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