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Study · Non-randomized trial · n = 58 · 2017

5 results

Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis.

Seki S, Hirano N, Kawaguchi Y, Nakano M, Yasuda T, Suzuki K, Watanabe K, Makino H, Kanamori M, Kimura T

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society23 Jan 2017Cited by 67 (Europe PMC)

PMID28116510 (opens in a new tab)DOI10.1007/s00586-017-4959-0 (opens in a new tab)PepBankPUB-28116510
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialSafety outcome

    In osteoporotic Japanese women undergoing spinal deformity surgery, adjacent vertebral fractures were less common with teriparatide than bisphosphonates.

    In plain wordsIn Japanese women with osteoporosis, adjacent spine fractures after surgery were less common with teriparatide than bisphosphonates.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseAdjacent vertebral fractures
    Study

    n = 58

    Comparator
    Low-dose bisphosphonates
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.
    3 context sentences
    Summary · context
    Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion.
    Summary · context
    Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age.
    Summary · context
    Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.
  2. 02HumanNon-randomized trialEfficacy outcome

    In osteoporotic Japanese women undergoing spinal deformity surgery, implant failure was less common with teriparatide than bisphosphonates.

    In plain wordsIn Japanese women with osteoporosis, implant failure after spine surgery was less common with teriparatide than bisphosphonates.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseImplant failure
    Study

    n = 58

    Comparator
    Low-dose bisphosphonates
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.
    3 context sentences
    Summary · context
    Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion.
    Summary · context
    Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age.
    Summary · context
    Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.
  3. 03HumanNon-randomized trialEfficacy outcome

    In osteoporotic Japanese women undergoing spinal deformity surgery, fusion failure was less common with teriparatide than bisphosphonates.

    In plain wordsIn Japanese women with osteoporosis, spine fusion failure was less common with teriparatide than bisphosphonates.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseFusion failure
    Study

    n = 58

    Comparator
    Low-dose bisphosphonates
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.
    3 context sentences
    Summary · context
    Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion.
    Summary · context
    Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age.
    Summary · context
    Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.
  4. 04HumanNon-randomized trialEfficacy outcome

    In osteoporotic Japanese women undergoing spinal deformity surgery, poor pain outcomes were less common with teriparatide than bisphosphonates.

    In plain wordsIn Japanese women with osteoporosis, poor pain outcomes after spine surgery were less common with teriparatide than bisphosphonates.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePoor pain outcomes
    Study

    n = 58

    Comparator
    Low-dose bisphosphonates
    Outcome group
    Pain · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.
    3 context sentences
    Summary · context
    Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion.
    Summary · context
    Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age.
    Summary · context
    Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.
  5. 05HumanNon-randomized trialEfficacy outcome

    In osteoporotic Japanese women undergoing spinal deformity surgery, poor ODI outcomes were less common with teriparatide than bisphosphonates.

    In plain wordsIn Japanese women with osteoporosis, poor disability outcomes after spine surgery were less common with teriparatide than bisphosphonates.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePoor ODI outcomes
    Study

    n = 58

    Comparator
    Low-dose bisphosphonates
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.
    3 context sentences
    Summary · context
    Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion.
    Summary · context
    Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age.
    Summary · context
    Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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