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Study · In vitro (cells) · 2017

13 results

ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy.

Ivashko-Pachima Y, Sayas CL, Malishkevich A, Gozes I

Molecular psychiatry24 Jan 2017Cited by 82 (Europe PMC)

PMID28115743 (opens in a new tab)DOI10.1038/mp.2016.255 (opens in a new tab)PepBankPUB-28115743
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In N1E-115 neuroblastoma cells, NAP increased endogenous EB1 comet density.

    In plain wordsIn cells, NAP increased the density of EB1 comets.

    Peptide
    Davunetide
    Outcome
    IncreaseEndogenous EB1 comet density
    Study

    n: not reported in source

    N1E-115 neuroblastoma neuronal model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We showed, for we believe the first time, that NAP augmented endogenous EB1 comet density in the N1E-115 neuroblastoma neuronal model.
  2. 02LabIn vitro (cells)Mechanism

    In the neuroblastoma neuronal model, NAP increased EB1 comet amounts.

    In plain wordsIn cells, NAP increased EB1 comet amounts.

    Peptide
    Davunetide
    Outcome
    IncreaseEB1 comet amounts
    Study

    n: not reported in source

    N1E-115 neuroblastoma neuronal model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAP increased comet amounts, length and speed.
    2 context sentences
    Summary · context
    We showed, for we believe the first time, that NAP augmented endogenous EB1 comet density in the N1E-115 neuroblastoma neuronal model.
    Summary · context
    This finding was substantiated by cell transfection with fluorescent EB1 and live cell imaging.
  3. 03LabIn vitro (cells)Mechanism

    In the neuroblastoma neuronal model, NAP increased EB1 comet length.

    In plain wordsIn cells, NAP increased EB1 comet length.

    Peptide
    Davunetide
    Outcome
    IncreaseEB1 comet length
    Study

    n: not reported in source

    N1E-115 neuroblastoma neuronal model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAP increased comet amounts, length and speed.
    2 context sentences
    Summary · context
    We showed, for we believe the first time, that NAP augmented endogenous EB1 comet density in the N1E-115 neuroblastoma neuronal model.
    Summary · context
    This finding was substantiated by cell transfection with fluorescent EB1 and live cell imaging.
  4. 04LabIn vitro (cells)Mechanism

    In the neuroblastoma neuronal model, NAP increased EB1 comet speed.

    In plain wordsIn cells, NAP increased EB1 comet speed.

    Peptide
    Davunetide
    Outcome
    IncreaseEB1 comet speed
    Study

    n: not reported in source

    N1E-115 neuroblastoma neuronal model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAP increased comet amounts, length and speed.
    2 context sentences
    Summary · context
    We showed, for we believe the first time, that NAP augmented endogenous EB1 comet density in the N1E-115 neuroblastoma neuronal model.
    Summary · context
    This finding was substantiated by cell transfection with fluorescent EB1 and live cell imaging.
  5. 05LabIn vitro (cells)Mechanism

    Under zinc intoxication, NAP promoted EB1 recruitment to microtubules.

    In plain wordsIn cells under zinc intoxication, NAP promoted EB1 recruitment to microtubules.

    Peptide
    Davunetide
    Outcome
    IncreaseEB1 recruitment to microtubules
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication.
  6. 06LabIn vitro (cells)Mechanism

    Under zinc intoxication, NAP promoted EB3 recruitment to microtubules.

    In plain wordsIn cells under zinc intoxication, NAP promoted EB3 recruitment to microtubules.

    Peptide
    Davunetide
    Outcome
    IncreaseEB3 recruitment to microtubules
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication.
  7. 07LabIn vitro (cells)Mechanism

    Under zinc intoxication, NAP promoted Tau recruitment to microtubules.

    In plain wordsIn cells under zinc intoxication, NAP promoted Tau recruitment to microtubules.

    Peptide
    Davunetide
    Outcome
    IncreaseTau recruitment to microtubules
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication.
  8. 08LabIn vitro (cells)Efficacy outcome

    In NIH3T3 cells without Tau transfection, NAP did not protect against zinc intoxication.

    In plain wordsIn cells without Tau transfection, NAP did not protect against zinc intoxication.

    Peptide
    Davunetide
    Outcome
    No significant changeProtection against zinc intoxication without Tau transfection
    Study

    n: not reported in source

    NIH3T3 fibroblasts
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, NAP did not protect NIH3T3 cells against zinc intoxication, unless these cells were transfected with Tau.
  9. 09LabIn vitro (cells)Efficacy outcome

    In Tau-transfected NIH3T3 cells, NAP protected against zinc intoxication.

    In plain wordsIn cells with Tau transfection, NAP protected against zinc intoxication.

    Peptide
    Davunetide
    Outcome
    IncreaseProtection against zinc intoxication with Tau transfection
    Study

    n: not reported in source

    Tau-transfected NIH3T3 fibroblasts
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, NAP did not protect NIH3T3 cells against zinc intoxication, unless these cells were transfected with Tau.
  10. 10LabOther designMechanism

    In molecular experiments, NAP enhanced EB3 homodimer formation.

    In plain wordsIn lab tests, NAP increased EB3 homodimer formation.

    Peptide
    Davunetide
    Outcome
    IncreaseEB3 homodimer formation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication.
  11. 11LabOther designMechanism

    In molecular experiments, NAP decreased EB1–EB3 heterodimer content.

    In plain wordsIn lab tests, NAP decreased EB1–EB3 heterodimer content.

    Peptide
    Davunetide
    Outcome
    DecreaseEB1–EB3 heterodimer content
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication.
  12. 12LabOther designMechanism

    In molecular experiments, NAP increased EB1-Tau interactions 20-fold.

    In plain wordsIn lab tests, NAP increased interactions between EB1 and Tau.

    Peptide
    Davunetide
    Outcome
    IncreaseEB1–Tau interaction
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    EB1-Tau interaction increase
    20 fold
    NAP

    Source sentences

    Summary
    At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication.
  13. 13LabOther designMechanism

    In molecular experiments, NAP increased EB3-Tau interactions 20-fold.

    In plain wordsIn lab tests, NAP increased interactions between EB3 and Tau.

    Peptide
    Davunetide
    Outcome
    IncreaseEB3–Tau interaction
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    EB3-Tau interaction increase
    20 fold
    NAP

    Source sentences

    Summary
    At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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