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Study · Animal study (in vivo) · mouse · 2016

2 results

[Evaluation of the antitumor potential of cerebrolysin].

Gromova OA, Pronin AV, Torshin IY, Kalacheva AG, Filimonova MV, Demidov VI, Gogoleva IV, Grishina TR

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2016

PMID28091504 (opens in a new tab)DOI10.17116/jnevro201611611169-77 (opens in a new tab)PepBankPUB-28091504
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with Lewis lung carcinoma, cerebrolysin inhibited tumor growth versus control, with a reported rate reduction of 10-15%.

    In plain wordsIn mice with lung carcinoma, cerebrolysin reduced tumor growth compared with control.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseTumor growth rate
    Study

    micen = 60

    Lewis lung carcinoma
    Comparator
    Control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    524 and 1800 mg/kg · intraperitonealAs given in this study (mice).

    Source sentences

    Summary
    An impact of the drug was accompanied by the inhibition of the tumor growth rate by 10-15% (p<0.05).
    3 context sentences
    Summary · context
    Compared with the control group (n=20), cerebrolysin induced growth inhibition of LLC during the treatment (7 to 16 days).
    Summary · context
    To investigate the effect of cerebrolysin on the growth and metastasis of malignant tumors in mice (a model of lung carcinoma Lewis).
    Summary · context
    Experimental animals were administered a single intraperitoneal injection of cerebrolysin in doses of 524 mg/kg (n=20) and 1800 mg/kg (n=20) daily from 2 to 16 days after tumor transplantation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with Lewis lung carcinoma, large metastases decreased by 30-50% as cerebrolysin dose increased.

    In plain wordsIn mice with lung carcinoma, higher cerebrolysin doses reduced large metastases compared with lower doses.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseLarge metastases
    Study

    micen = 40

    Lewis lung carcinoma
    Comparator
    Lower cerebrolysin dose
    Outcome group
    Tumor growth · Cancer
    Studied dose
    524 and 1800 mg/kg · intraperitonealAs given in this study (mice).

    Source sentences

    Summary
    Cerebrolysin demonstrated a dose-dependent effect of reducing the large number of metastases: a number of large metastases significantly decreased by 30-50% with the increase of cerebrolysin dose (p=0.01).
    2 context sentences
    Summary · context
    To investigate the effect of cerebrolysin on the growth and metastasis of malignant tumors in mice (a model of lung carcinoma Lewis).
    Summary · context
    Experimental animals were administered a single intraperitoneal injection of cerebrolysin in doses of 524 mg/kg (n=20) and 1800 mg/kg (n=20) daily from 2 to 16 days after tumor transplantation.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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