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Study · Randomized controlled trial · n = 68 · 2017

3 results

Intranasal oxytocin increases facial expressivity, but not ratings of trustworthiness, in patients with schizophrenia and healthy controls.

Woolley JD, Chuang B, Fussell C, Scherer S, Biagianti B, Fulford D, Mathalon DH, Vinogradov S

Psychological medicine16 Jan 2017Cited by 23 (Europe PMC)

PMID28091349 (opens in a new tab)PMCIDPMC6939989 (opens in a new tab)DOI10.1017/s0033291716003433 (opens in a new tab)PepBankPUB-28091349
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In people with schizophrenia and healthy controls, oxytocin did not affect ratings of facial trustworthiness.

    In plain wordsIn people with schizophrenia and healthy controls, oxytocin did not change ratings of face trustworthiness, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeRatings of facial trustworthiness
    Study

    n = 68

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    While oxytocin administration did not affect ratings of facial trustworthiness
    1 context sentence
    Summary · context
    We investigated the effects of oxytocin on facial emotional expressivity while participants performed a facial trustworthiness rating task in 33 individuals with schizophrenia and 35 age-matched healthy controls using a double-blind, placebo-controlled, cross-over design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy controls, oxytocin increased facial expressivity only at trend level compared with placebo, which was not significant.

    In plain wordsIn healthy adults, oxytocin showed only a trend toward more facial expression than placebo, which was not significant.

    Peptide
    Oxytocin
    Outcome
    No significant changeFacial expressivity in healthy controls
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    and at trend level in healthy controls (Z = -1.87, p = 0.06).
    1 context sentence
    Summary · context
    We investigated the effects of oxytocin on facial emotional expressivity while participants performed a facial trustworthiness rating task in 33 individuals with schizophrenia and 35 age-matched healthy controls using a double-blind, placebo-controlled, cross-over design.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In individuals with schizophrenia, oxytocin significantly increased facial expressivity compared with placebo.

    In plain wordsIn people with schizophrenia, oxytocin increased facial expressions more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseFacial expressivity in schizophrenia
    Study

    n = 33

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    it significantly increased facial expressivity in individuals with schizophrenia (Z = -2.33, p = 0.02)
    1 context sentence
    Summary · context
    We investigated the effects of oxytocin on facial emotional expressivity while participants performed a facial trustworthiness rating task in 33 individuals with schizophrenia and 35 age-matched healthy controls using a double-blind, placebo-controlled, cross-over design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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