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Study · Observational study · n = 129 · 2017

6 results

Effects of cerebrolysin on functional recovery in patients with severe disability after traumatic brain injury: A historical cohort study.

Khalili H, Niakan A, Ghaffarpasand F

Clinical neurology and neurosurgery15 Nov 2016Cited by 24 (Europe PMC)

PMID27871029 (opens in a new tab)DOI10.1016/j.clineuro.2016.11.011 (opens in a new tab)PepBankPUB-27871029
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In adults with severe disability after TBI, Cerebrolysin was linked to higher GOSE at 3 months than no Cerebrolysin.

    In plain wordsIn adults with severe disability after TBI, Cerebrolysin was linked to higher GOSE at 3 months than no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGOSE at 3 months
    Study

    n = 129

    Comparator
    No Cerebrolysin
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    10mL daily · intravenous · 30daysAs given in this study (human).

    Measurements

    p
    0.017
    GOSE at 3-month

    Source sentences

    Summary
    We found that GOSE at 3-month (p=0.017) and 6-month (p=0.009) was significantly higher in those receiving cerebrolysin.
    3 context sentences
    Summary · context
    This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma.
    Summary · context
    Some patients received cerebrolysin (n=65) and some did not (n=64).
    Summary · context
    Cerebrolysin was administered intravenously in 10mL dosage daily for 30days.
  2. 02HumanObservational studyEfficacy outcome

    In adults with severe disability after TBI, Cerebrolysin was linked to higher GOSE at 6 months than no Cerebrolysin.

    In plain wordsIn adults with severe disability after TBI, Cerebrolysin was linked to higher GOSE at 6 months than no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGOSE at 6 months
    Study

    n = 129

    Comparator
    No Cerebrolysin
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    10mL daily · intravenous · 30daysAs given in this study (human).

    Measurements

    p
    0.009
    GOSE at 6-month

    Source sentences

    Summary
    We found that GOSE at 3-month (p=0.017) and 6-month (p=0.009) was significantly higher in those receiving cerebrolysin.
    3 context sentences
    Summary · context
    This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma.
    Summary · context
    Some patients received cerebrolysin (n=65) and some did not (n=64).
    Summary · context
    Cerebrolysin was administered intravenously in 10mL dosage daily for 30days.
  3. 03HumanObservational studySafety outcome

    In adults with severe disability after TBI, Cerebrolysin was linked to lower mortality than no Cerebrolysin.

    In plain wordsIn adults with severe disability after TBI, Cerebrolysin was linked to lower mortality than no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMortality rate
    Study

    n = 129

    Comparator
    No Cerebrolysin
    Outcome group
    Mortality · Whole body
    Studied dose
    10mL daily · intravenous · 30daysAs given in this study (human).

    Source sentences

    Summary
    Cerebrolysin administration was associated with lower mortality rate, and higher good recovery after 6 month of therapy (p=0.024).
    3 context sentences
    Summary · context
    This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma.
    Summary · context
    Some patients received cerebrolysin (n=65) and some did not (n=64).
    Summary · context
    Cerebrolysin was administered intravenously in 10mL dosage daily for 30days.
  4. 04HumanObservational studyEfficacy outcome

    In adults with severe disability after TBI, Cerebrolysin was linked to higher good recovery after 6 months than no Cerebrolysin.

    In plain wordsIn adults with severe disability after TBI, Cerebrolysin was linked to higher good recovery after 6 months than no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGood recovery after 6 months
    Study

    n = 129

    Comparator
    No Cerebrolysin
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    10mL daily · intravenous · 30daysAs given in this study (human).

    Measurements

    p
    0.024
    Good recovery after 6 month

    Source sentences

    Summary
    Cerebrolysin administration was associated with lower mortality rate, and higher good recovery after 6 month of therapy (p=0.024).
    3 context sentences
    Summary · context
    This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma.
    Summary · context
    Some patients received cerebrolysin (n=65) and some did not (n=64).
    Summary · context
    Cerebrolysin was administered intravenously in 10mL dosage daily for 30days.
  5. 05HumanObservational studyEfficacy outcome

    In adults with severe disability after TBI, Cerebrolysin was linked to higher favorable and lower unfavorable outcome than no Cerebrolysin.

    In plain wordsIn adults with severe disability after TBI, Cerebrolysin was linked to more favorable and fewer unfavorable outcomes than no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseFavorable and unfavorable outcome
    Study

    n = 129

    Comparator
    No Cerebrolysin
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    10mL daily · intravenous · 30daysAs given in this study (human).

    Measurements

    p
    0.043
    Favorable and unfavorable outcome

    Source sentences

    Summary
    Cerebrolysin administration was also associated with higher favorable and lower unfavorable outcome (p=0.043).
    3 context sentences
    Summary · context
    This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma.
    Summary · context
    Some patients received cerebrolysin (n=65) and some did not (n=64).
    Summary · context
    Cerebrolysin was administered intravenously in 10mL dosage daily for 30days.
  6. 06HumanObservational studySafety outcome

    In adults with severe disability after TBI, Cerebrolysin was linked to higher seizure rates than no Cerebrolysin.

    In plain wordsIn adults with severe disability after TBI, Cerebrolysin was linked to higher seizure rates than no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSeizure rate
    Study

    n = 129

    Comparator
    No Cerebrolysin
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    10mL daily · intravenous · 30daysAs given in this study (human).

    Measurements

    p
    0.042
    Seizure rate

    Source sentences

    Summary
    Cerebrolysin was associated with higher seizure rate (p=0.042).
    3 context sentences
    Summary · context
    This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma.
    Summary · context
    Some patients received cerebrolysin (n=65) and some did not (n=64).
    Summary · context
    Cerebrolysin was administered intravenously in 10mL dosage daily for 30days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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