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Study · Animal study (in vivo) · rat · 2018

9 results

Potential effect of mechano growth factor E-domain peptide on axonal guidance growth in primary cultured cortical neurons of rats.

Liu M, Niu X, Zhou G, Jia Z, Li P, Fan Y

Journal of tissue engineering and regenerative medicine8 Jun 2017Cited by 5 (Europe PMC)

PMID27863093 (opens in a new tab)DOI10.1002/term.2364 (opens in a new tab)PepBankPUB-27863093
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with traumatic brain injury, rats injected with MGF-Ct24E started eating and drinking within 14 days, which the authors read as promoting rehabilitation.

    In plain wordsIn rats with brain injury, those given MGF-Ct24E started eating and drinking within 14 days. No comparison group is stated.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseRecovery of eating and drinking after traumatic brain injury
    Study

    ratn: not reported in source

    traumatic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Rats injected with MGF-Ct24E start eating and drinking within 14 days, indicating that MGF-Ct24E can promote rehabilitation.
    1 context sentence
    Summary · context
    To identify the certain mechanism of MGF-Ct24E on neuronal guidance and growth, adult rats are subjected to intramuscular injection of MGF-Ct24E after traumatic brain injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with traumatic brain injury, MGF-Ct24E treatment significantly inhibited haemorrhage in brain sections.

    In plain wordsIn rats with brain injury, MGF-Ct24E reduced bleeding in the brain.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseHaemorrhage after traumatic brain injury
    Study

    ratn: not reported in source

    traumatic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    HE staining and immunohistochemistry assays of brain section slices reveal that MGF-Ct24E treatment can significantly inhibit the haemorrhage of traumatic brain injury
    1 context sentence
    Summary · context
    To identify the certain mechanism of MGF-Ct24E on neuronal guidance and growth, adult rats are subjected to intramuscular injection of MGF-Ct24E after traumatic brain injury.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with traumatic brain injury, MGF-Ct24E treatment promoted Netrin-1 expression in brain sections.

    In plain wordsIn rats with brain injury, MGF-Ct24E raised the level of Netrin-1 in the brain.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseNetrin-1 expression in injured brain (immunohistochemistry)
    Study

    ratn: not reported in source

    traumatic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    HE staining and immunohistochemistry assays of brain section slices reveal that MGF-Ct24E treatment can significantly inhibit the haemorrhage of traumatic brain injury and promote expression of Netrin-1.
    1 context sentence
    Summary · context
    To identify the certain mechanism of MGF-Ct24E on neuronal guidance and growth, adult rats are subjected to intramuscular injection of MGF-Ct24E after traumatic brain injury.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with nerve injury, MGF-Ct24E promoted Netrin-1 protein expression on Western blot.

    In plain wordsIn rats with nerve injury, MGF-Ct24E raised the level of Netrin-1 protein.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseNetrin-1 expression after nerve injury (Western blot)
    Study

    ratn: not reported in source

    traumatic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Further investigation of protein expression by Western blot assay shows that MGF-Ct24E promotes expression of Netrin-1 and DCC after nerve injury.
    1 context sentence
    Summary · context
    To identify the certain mechanism of MGF-Ct24E on neuronal guidance and growth, adult rats are subjected to intramuscular injection of MGF-Ct24E after traumatic brain injury.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with nerve injury, MGF-Ct24E promoted DCC protein expression on Western blot.

    In plain wordsIn rats with nerve injury, MGF-Ct24E raised the level of DCC protein.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseDCC expression after nerve injury (Western blot)
    Study

    ratn: not reported in source

    traumatic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Further investigation of protein expression by Western blot assay shows that MGF-Ct24E promotes expression of Netrin-1 and DCC after nerve injury.
    1 context sentence
    Summary · context
    To identify the certain mechanism of MGF-Ct24E on neuronal guidance and growth, adult rats are subjected to intramuscular injection of MGF-Ct24E after traumatic brain injury.
  6. 06LabIn vitro (cells)Efficacy outcome

    In primary cultured rat cortical neurons, MGF-Ct24E protected neurons against nerve injury in an MTT assay.

    In plain wordsIn rat nerve cells in a dish, MGF-Ct24E protected the cells against injury.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseNeuron viability against nerve injury (MTT)
    Study

    ratn: not reported in source

    primary cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTT assay shows that MGF-Ct24E can significantly protect primary cortical neurons against nerve injury.
    1 context sentence
    Summary · context
    Here, we investigate the effect of MGF-Ct24E on the expression of Netrin-1 and DCC in primary cultured cortical neurons in vitro and the adult rat brain in vivo.
  7. 07LabIn vitro (cells)Efficacy outcome

    In primary cultured rat cortical neurons, MGF-Ct24E increased axonal elongation at 0.5 and 1.0 μg/ml.

    In plain wordsIn rat nerve cells in a dish, MGF-Ct24E made nerve fibres grow longer.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseAxonal elongation
    Study

    ratn: not reported in source

    primary cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.5 and 1.0 μg/mlAs given in this study (rat).

    Source sentences

    Summary
    There is a significant increase in axonal elongation after MGF-Ct24E treatment at concentrations of 0.5 and 1.0 μg/ml.
    1 context sentence
    Summary · context
    Here, we investigate the effect of MGF-Ct24E on the expression of Netrin-1 and DCC in primary cultured cortical neurons in vitro and the adult rat brain in vivo.
  8. 08LabIn vitro (cells)Mechanism

    In primary cultured rat cortical neurons, MGF-Ct24E promoted Netrin-1 expression.

    In plain wordsIn rat nerve cells in a dish, MGF-Ct24E raised the level of Netrin-1, a nerve guidance protein.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseNetrin-1 expression in cortical neurons
    Study

    ratn: not reported in source

    primary cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Real-time polymerase chain reaction assay indicates that MGF-Ct24E can effectively promote the expression of Netrin-1 and DCC in primary cultured cortical neurons.
    1 context sentence
    Summary · context
    Here, we investigate the effect of MGF-Ct24E on the expression of Netrin-1 and DCC in primary cultured cortical neurons in vitro and the adult rat brain in vivo.
  9. 09LabIn vitro (cells)Mechanism

    In primary cultured rat cortical neurons, MGF-Ct24E promoted expression of the Netrin-1 receptor DCC.

    In plain wordsIn rat nerve cells in a dish, MGF-Ct24E raised the level of DCC, the receptor for Netrin-1.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseDCC expression in cortical neurons
    Study

    ratn: not reported in source

    primary cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Real-time polymerase chain reaction assay indicates that MGF-Ct24E can effectively promote the expression of Netrin-1 and DCC in primary cultured cortical neurons.
    1 context sentence
    Summary · context
    Here, we investigate the effect of MGF-Ct24E on the expression of Netrin-1 and DCC in primary cultured cortical neurons in vitro and the adult rat brain in vivo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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