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Study · Not a test of the peptide alone · 2017

6 results

Age and duration of testosterone therapy predict time to return of sperm count after human chorionic gonadotropin therapy.

Kohn TP, Louis MR, Pickett SM, Lindgren MC, Kohn JR, Pastuszak AW, Lipshultz LI

Fertility and sterility14 Nov 2016Cited by 52 (Europe PMC)

PMID27855957 (opens in a new tab)PMCIDPMC5292276 (opens in a new tab)DOI10.1016/j.fertnstert.2016.10.004 (opens in a new tab)PepBankPUB-27855957
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

  1. 01HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome

    After testosterone cessation and hCG/SERM therapy, 46 men (70%) achieved a total motile count greater than 5 million sperm.

    In plain wordsAfter testosterone cessation and hCG/SERM therapy, 46 men (70%) achieved more than 5 million moving sperm.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicableSperm recovery
    Study

    n = 66

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Men achieving sperm recovery
    46 men
    After testosterone cessation and hCG/SERM therapy, within 12 months
    Men achieving sperm recovery
    70%
    After testosterone cessation and hCG/SERM therapy, within 12 months
    Total motile count threshold for sperm recovery
    > 5 million sperm
    Sperm recovery criterion within 12 months

    Source sentences

    Summary
    A TMC of greater than 5 million sperm was achieved by 46 men (70%).
    4 context sentences
    Summary · context
    Clinical retrospective study.
    Summary · context
    Sixty-six men who presented with infertility after T use.
    Summary · context
    T cessation and combination high-dose hCG and selective estrogen modulator (SERM) therapy.
    Summary · context
    Whether patients successfully achieved or failed to achieve a total motile count (TMC) of greater than 5 million sperm within 12 months of T cessation and initiation of therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  2. 02HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyOther

    In men receiving hCG/SERM after testosterone cessation, greater age correlated with longer time to sperm recovery at 6 and 12 months.

    In plain wordsIn men receiving hCG/SERM after testosterone cessation, older age was linked to longer sperm recovery at 6 and 12 months.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseAge and time to sperm recovery
    Study

    n = 66

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Both increased age and duration of T use directly correlated with time to sperm recovery at both 6 and 12 months of hCG/SERM therapy.
    4 context sentences
    Summary · context
    Clinical retrospective study.
    Summary · context
    Sixty-six men who presented with infertility after T use.
    Summary · context
    T cessation and combination high-dose hCG and selective estrogen modulator (SERM) therapy.
    Summary · context
    Whether patients successfully achieved or failed to achieve a total motile count (TMC) of greater than 5 million sperm within 12 months of T cessation and initiation of therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  3. 03HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyOther

    In men receiving hCG/SERM after testosterone cessation, longer testosterone use correlated with longer time to sperm recovery at 6 and 12 months.

    In plain wordsIn men receiving hCG/SERM after testosterone cessation, longer testosterone use was linked to longer sperm recovery at 6 and 12 months.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseTestosterone duration and time to sperm recovery
    Study

    n = 66

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Both increased age and duration of T use directly correlated with time to sperm recovery at both 6 and 12 months of hCG/SERM therapy.
    4 context sentences
    Summary · context
    Clinical retrospective study.
    Summary · context
    Sixty-six men who presented with infertility after T use.
    Summary · context
    T cessation and combination high-dose hCG and selective estrogen modulator (SERM) therapy.
    Summary · context
    Whether patients successfully achieved or failed to achieve a total motile count (TMC) of greater than 5 million sperm within 12 months of T cessation and initiation of therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  4. 04HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyOther

    In men receiving hCG/SERM after testosterone cessation, age more consistently limited sperm recovery, while duration of testosterone use had less influence at 12 months than at 6 months.

    In plain wordsIn men getting hCG/SERM after stopping testosterone, age limited sperm recovery more consistently, and testosterone duration mattered less at 12 months than at 6.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicableRelative influence of age and testosterone-use duration on sperm recovery
    Study

    n = 66

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Age more consistently limited sperm recovery, while duration of T use had less influence at 12 months than at 6 months.
    4 context sentences
    Summary · context
    Clinical retrospective study.
    Summary · context
    Sixty-six men who presented with infertility after T use.
    Summary · context
    T cessation and combination high-dose hCG and selective estrogen modulator (SERM) therapy.
    Summary · context
    Whether patients successfully achieved or failed to achieve a total motile count (TMC) of greater than 5 million sperm within 12 months of T cessation and initiation of therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  5. 05HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyEfficacy outcome

    During hCG/SERM therapy, 64.8% of azoospermic men versus 91.7% of cryptozoospermic men achieved TMC greater than 5 million sperm at 12 months, although this did not predict a failure of sperm recovery.

    In plain wordsWith hCG/SERM, fewer men with no sperm than men with very low counts reached recovery at 12 months, but this did not predict failure.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseRecovery in azoospermic men
    Study

    n: not reported in source

    Comparator
    Cryptozoospermic men
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Men achieving TMC greater than 5 million sperm
    64.8%
    Azoospermic men, hCG/SERM, 12 months
    Men achieving TMC greater than 5 million sperm
    91.7%
    Cryptozoospermic men, hCG/SERM, 12 months

    Source sentences

    Summary
    Only 64.8% of azoospermic men achieved a TMC greater than 5 million sperm at 12 months, compared with 91.7% of cryptozoospermic men, yet this did not predict a failure of sperm recovery.
    4 context sentences
    Summary · context
    Clinical retrospective study.
    Summary · context
    Sixty-six men who presented with infertility after T use.
    Summary · context
    T cessation and combination high-dose hCG and selective estrogen modulator (SERM) therapy.
    Summary · context
    Whether patients successfully achieved or failed to achieve a total motile count (TMC) of greater than 5 million sperm within 12 months of T cessation and initiation of therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  6. 06HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studyOther

    In men receiving hCG/SERM, azoospermic versus cryptozoospermic status did not predict failure of sperm recovery.

    In plain wordsIn men receiving hCG/SERM, initial absence versus very low numbers of sperm did not predict recovery failure.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    No significant changeInitial sperm status and recovery failure
    Study

    n: not reported in source

    Comparator
    Cryptozoospermic men
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Only 64.8% of azoospermic men achieved a TMC greater than 5 million sperm at 12 months, compared with 91.7% of cryptozoospermic men, yet this did not predict a failure of sperm recovery.
    4 context sentences
    Summary · context
    Clinical retrospective study.
    Summary · context
    Sixty-six men who presented with infertility after T use.
    Summary · context
    T cessation and combination high-dose hCG and selective estrogen modulator (SERM) therapy.
    Summary · context
    Whether patients successfully achieved or failed to achieve a total motile count (TMC) of greater than 5 million sperm within 12 months of T cessation and initiation of therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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