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Study · In vitro (cells) · mouse · 2016

10 results

The human Ec peptide: the active core of a progression growth factor with species-specific mode of action.

Papageorgiou E, Philippou A, Armakolas A, Christopoulos PF, Dimakakos A, Koutsilieris M

Hormones (Athens, Greece)1 Jul 2016Cited by 9 (Europe PMC)

PMID27838607 (opens in a new tab)DOI10.14310/horm.2002.1699 (opens in a new tab)PepBankPUB-27838607
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human PC-3 prostate cancer cells, synthetic human Ec peptide (hEc) activated ERK1/2.

    In plain wordsIn prostate cancer cells in the lab, the human Ec peptide switched on the ERK1/2 signal.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseERK1/2 activation by hEc
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    activating ERK1/2 without affecting Akt phosphorylation in PC-3 cells
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  2. 02LabIn vitro (cells)Mechanism

    In human PC-3 prostate cancer cells, hEc did not affect Akt phosphorylation.

    In plain wordsIn prostate cancer cells in the lab, the human Ec peptide did not change Akt phosphorylation.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeAkt phosphorylation by hEc
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    without affecting Akt phosphorylation in PC-3 cells
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human PC-3 prostate cancer cells grown in 10% FBS, hEc at 5-50nM stimulated growth.

    In plain wordsIn prostate cancer cells in the lab, a narrow range of the human Ec peptide made cells grow in medium with 10% serum.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreasePC-3 cell growth in 10% FBS
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    5-50nMAs given in this study (human).

    Measurements

    hEc concentration
    5 to 50 nM
    PC-3 cells in 10% FBS

    Source sentences

    Summary
    A narrow concentration range of hEc (5-50nM) stimulated the growth of PC-3 cells grown in culture media supplemented with 10% FBS
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  4. 04LabIn vitro (cells)Efficacy outcome

    In human PC-3 prostate cancer cells grown in 0.5% FBS, hEc did not stimulate growth.

    In plain wordsIn prostate cancer cells in the lab, the human Ec peptide did not make cells grow in medium with 0.5% serum.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changePC-3 cell growth in 0.5% FBS
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    hEc did not stimulate the growth of PC-3 cells cultured with media containing 0.5% FBS
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  5. 05LabIn vitro (cells)Efficacy outcome

    In mouse C2C12 myoblasts, hEc did not stimulate growth under any culture condition.

    In plain wordsIn mouse muscle cells in the lab, the human Ec peptide did not stimulate growth under any culture condition.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeC2C12 myoblast growth with hEc
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    hEc did not stimulate the growth of PC-3 cells cultured with media containing 0.5% FBS or in mouse C2C12 myoblasts under any culture conditions
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  6. 06LabIn vitro (cells)Mechanism

    A neutralizing anti-human IGF-1Ec antibody blocked the activity of hEc in cells.

    In plain wordsIn lab tests, an antibody against IGF-1Ec blocked the activity of the human Ec peptide.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicablehEc activity blocked by anti-IGF-1Ec antibody
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The activity of hEc was blocked by a neutralizing anti-human IGF-1Ec antibody
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  7. 07LabIn vitro (cells)Mechanism

    A neutralizing anti-human IGF-1 receptor antibody did not block the activity of hEc in cells.

    In plain wordsIn lab tests, an antibody against the IGF-1 receptor did not block the activity of the human Ec peptide.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicablehEc activity and anti-IGF-1 receptor antibody
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The activity of hEc was blocked by a neutralizing anti-human IGF-1Ec antibody but not by a neutralizing anti-human IGF-1 receptor antibody
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  8. 08LabIn vitro (cells)Efficacy outcome

    Synthetic mouse Ec peptide was inactive in human PC-3 cells.

    In plain wordsIn human prostate cancer cells in the lab, the mouse version of the Ec peptide was inactive.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeSynthetic mouse Ec activity in human PC-3 cells
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthetic mouse Ec was inactive in human PC-3 cells
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.
  9. 09LabIn vitro (cells)Efficacy outcome

    Synthetic mouse Ec peptide significantly stimulated proliferation of mouse C2C12 myoblasts.

    In plain wordsIn mouse muscle cells in the lab, the mouse Ec peptide made the cells multiply.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseSynthetic mouse Ec effect on C2C12 proliferation
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    it stimulated significantly the proliferation of mouse C2C12.
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.

Studies that did not test the peptide alone1

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 10LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    Tests of synthetic hEc fragments located the active core of hEc in the last 4 amino acids of its C-terminal end.

    In plain wordsIn lab tests, the active part of the human Ec peptide lies in its last four amino acids.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableLocation of the active core of hEc
    Study

    humann: not reported in source

    PC-3 prostate cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    By analyzing the bioactivity of synthetic hEc fragments, we documented that hEc's active core is located in the last 4aa of its C-terminal end.
    1 context sentence
    Summary · context
    Using proliferation and mitogenic signaling assays, we tested their effect on PC-3 cells and C2C12 myoblasts at different doses and in different culture conditions.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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