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Study · Measured the body's own peptide · 2017

3 results

Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans.

Vassilakos G, Philippou A, Koutsilieris M

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society4 Nov 2016Cited by 11 (Europe PMC)

PMID27836414 (opens in a new tab)DOI10.1016/j.ghir.2016.11.001 (opens in a new tab)PepBankPUB-27836414
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelOther designMechanism

    In humans, initial evidence showed that the Ec peptide is differentially regulated during muscle regeneration after exercise-induced damage.

    In plain wordsIn people, the body's own Ec peptide appeared to change differently during muscle recovery after exercise damage.

    Peptide
    MGF / PEG-MGF
    Outcome
    Direction not reportedEc peptide regulation after exercise-induced muscle damage
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    Furthermore, initial evidence is provided that Ec peptide is differentially regulated during the process of muscle regeneration after exercise-induced damage in humans.
    1 context sentence
    Summary · context
    Protein lysates from a wide range of human and rodent tissues were immunoblotted with a rabbit anti-human Ec polyclonal antibody raised against the last 24 amino acids of the C-terminal of the Ec peptide.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelEx vivo tissueOther

    In human and rodent tissue lysates, the Ec peptide was present together with its precursor protein in a wide range of tissues.

    In plain wordsIn lab tests of human and rodent tissue, the body's own Ec peptide was found in many tissues.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableEc peptide presence in tissues
    Study

    human, rodentn: not reported in source

    Tissue lysates
    Outcome group
    Growth hormone and IGF-1 · Whole body

    Source sentences

    Summary
    We were able to confirm, for the first time, that the human Ec peptide and its rodent homologous Eb peptide are produced simultaneously with their precursor protein (pro-IGF-1Ec/Eb) in vivo, in a wide range of tissues (e.g. muscle, liver, heart).
    1 context sentence
    Summary · context
    Protein lysates from a wide range of human and rodent tissues were immunoblotted with a rabbit anti-human Ec polyclonal antibody raised against the last 24 amino acids of the C-terminal of the Ec peptide.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 03LabNot a test of MGF / PEG-MGF aloneEx vivo tissueMechanism

    In human muscle and liver lysates, furin digestion cleaved pro-IGF-1Ec to produce the free Ec peptide.

    In plain wordsIn lab tests of human muscle and liver, an enzyme called furin cut the precursor protein to release the Ec peptide.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableFurin cleavage of pro-IGF-1Ec
    Study

    humann: not reported in source

    Muscle and liver lysates
    Outcome group
    Growth hormone and IGF-1 · Whole body

    Source sentences

    Summary
    Proprotein convertase furin digestion of human muscle and liver protein lysates confirmed that the higher molecular form, pro-IGF-1Ec, can be cleaved to produce the free Ec peptide.
    1 context sentence
    Summary · context
    Protein lysates from a wide range of human and rodent tissues were immunoblotted with a rabbit anti-human Ec polyclonal antibody raised against the last 24 amino acids of the C-terminal of the Ec peptide.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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