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Study · Systematic review · n = 238 · 2017

3 results

Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis.

Williams DR, Bürkner PC

Psychoneuroendocrinology25 Oct 2016Cited by 43 (Europe PMC)

PMID27825069 (opens in a new tab)DOI10.1016/j.psyneuen.2016.10.013 (opens in a new tab)PepBankPUB-27825069
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a Bayesian meta-analysis of eight randomized trials in schizophrenia, intranasal oxytocin did not improve any aspect of symptomatology.

    In plain wordsIn people with schizophrenia, intranasal oxytocin did not improve any aspect of symptoms in a pooled analysis of eight trials.

    Peptide
    Oxytocin
    Outcome
    No significant changeOverall schizophrenia symptoms
    Study

    n = 238

    Outcome group
    Psychiatric symptoms · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Eight RCTs (n=238) were included in the present study and we found that oxytocin did not improve any aspect of symptomology in schizophrenic patients
    1 context sentence
    Title · context
    Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis.
  2. 02HumanSystematic reviewEfficacy outcome

    In people with schizophrenia, there was moderate evidence for no effect of oxytocin on negative symptoms.

    In plain wordsIn people with schizophrenia, pooled trials gave moderate evidence that oxytocin had no effect on negative symptoms.

    Peptide
    Oxytocin
    Outcome
    No significant changeNegative symptoms of schizophrenia
    Study

    n = 238

    Outcome group
    Psychiatric symptoms · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    there was moderate evidence in favor of the null (no effect of oxytocin) for negative symptoms.
    1 context sentence
    Title · context
    Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis.
  3. 03HumanSystematic reviewEfficacy outcome

    In a multivariate comparison between symptom types, oxytocin was not especially beneficial for negative symptoms.

    In plain wordsIn people with schizophrenia, oxytocin was not especially beneficial for negative symptoms compared with other symptom types.

    Peptide
    Oxytocin
    Outcome
    No significant changeNegative versus other symptom types
    Study

    n = 238

    Outcome group
    Psychiatric symptoms · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Multivariate comparisons between symptom types revealed that oxytocin was not especially beneficial for treating negative symptoms.
    1 context sentence
    Title · context
    Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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