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Study · In vitro (cells) · bovine · 2016

2 results

Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide.

Heikal L, Ghezzi P, Mengozzi M, Stelmaszczuk B, Feelisch M, Ferns GA

Hypoxia (Auckland, N.Z.)16 Aug 2016Cited by 15 (Europe PMC)

PMID27800514 (opens in a new tab)PMCIDPMC5085277 (opens in a new tab)DOI10.2147/hp.s104377 (opens in a new tab)PepBankPUB-27800514
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In bovine aortic endothelial cells under hypoxia, pHBSP enhanced scratch closure by promoting cell migration and proliferation.

    In plain wordsIn cells, pHBSP helped a scratched cell layer close under low oxygen, by boosting cell movement and growth.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseScratch closure under hypoxia (1% O2)
    Study

    bovinen: not reported in source

    Bovine aortic endothelial cells, scratch assay
    Outcome group
    Wound healing · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    under hypoxic conditions, EPO and pHBSP enhanced scratch closure by promoting cell migration and proliferation, but did not show any effect under normoxic conditions.
    1 context sentence
    Summary · context
    The cytoprotective effects of erythropoietin (EPO) and an EPO-related nonerythropoietic analog, pyroglutamate helix B surface peptide (pHBSP), were investigated in an in vitro model of bovine aortic endothelial cell injury under normoxic (21% O2) and hypoxic (1% O2) conditions.
  2. 02LabIn vitro (cells)Efficacy outcome

    In bovine aortic endothelial cells under normoxia, pHBSP did not affect scratch closure.

    In plain wordsIn cells, pHBSP had no effect on scratch closure under normal oxygen.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeScratch closure under normoxia (21% O2)
    Study

    bovinen: not reported in source

    Bovine aortic endothelial cells, scratch assay
    Outcome group
    Wound healing · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but did not show any effect under normoxic conditions.
    1 context sentence
    Summary · context
    The cytoprotective effects of erythropoietin (EPO) and an EPO-related nonerythropoietic analog, pyroglutamate helix B surface peptide (pHBSP), were investigated in an in vitro model of bovine aortic endothelial cell injury under normoxic (21% O2) and hypoxic (1% O2) conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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