Ghrelin-Induced Enhancement of Vasopressin and Oxytocin Secretion in Rat Neurohypophyseal Cell Cultures.

Gálfi M, Radács M, Molnár Z, Budai I, Tóth G, Pósa A, Kupai K, Szalai Z, Szabó R, Molnár HA, Gardi J, László FA, Varga C

Journal of molecular neuroscience : MN17 Oct 2016Cited by 9 (Europe PMC)

PMID27752928DOI10.1007/s12031-016-0850-4PepBankPUB-27752928

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelIn vitro (cells)Mechanism
In rat neurohypophyseal cultures, ghrelin increased endogenous oxytocin production in a dose-dependent manner.
In plain wordsIn cells from rats, ghrelin increased the body's own oxytocin production.
Peptide
Oxytocin
Outcome
IncreaseOxytocin secretion after ghrelin
Study
ratn: not reported in source
Neurohypophyseal cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Significantly increased levels of vasopressin and oxytocin production were detected in the cell culture media following ghrelin administration, depending on the ghrelin doses.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2775292801
02LabEndogenous levelIn vitro (cells)Mechanism
In rat neurohypophyseal cultures, endogenous oxytocin rose more than vasopressin after ghrelin.
In plain wordsIn cells from rats, natural oxytocin increased more than vasopressin after ghrelin.
Peptide
Oxytocin
Outcome
IncreaseRelative oxytocin elevation
Study
ratn: not reported in source
Neurohypophyseal cell cultures
Comparator
Vasopressin elevation
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
The oxytocin level proved to be more elevated than that of vasopressin.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2775292802
03LabEndogenous levelIn vitro (cells)Mechanism
In rat neurohypophyseal cultures, prior ghrelin receptor antagonist administration completely blocked ghrelin-induced endogenous oxytocin secretion.
In plain wordsIn cells from rats, antagonist pretreatment blocked the ghrelin-induced rise in natural oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOxytocin secretion after antagonist pretreatment
Study
ratn: not reported in source
Neurohypophyseal cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
The increase of vasopressin and oxytocin secretion could be totally blocked by previous administration of the ghrelin receptor antagonist ([D-Lys³]-growth hormone-releasing peptide-6).
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2775292803
04LabEndogenous levelIn vitro (cells)Mechanism
In rat neurohypophyseal cultures, antagonist administration after ghrelin did not block the secretory response.
In plain wordsIn cells from rats, antagonist treatment after ghrelin did not block the natural oxytocin response.
Peptide
Oxytocin
Outcome
No significant changeOxytocin secretion after delayed antagonist
Study
ratn: not reported in source
Neurohypophyseal cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Application of the ghrelin receptor antagonist after ghrelin administration proved ineffective.
2 context sentences(design, population, supporting numbers)
Summary · context
The increase of vasopressin and oxytocin secretion could be totally blocked by previous administration of the ghrelin receptor antagonist ([D-Lys³]-growth hormone-releasing peptide-6).
Summary · context
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2775292804

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

05LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In rat neurohypophyseal cultures, the modified GHRP‑6 antagonist given before ghrelin completely blocked increased vasopressin secretion.
In plain wordsIn cells from rats, modified GHRP‑6 pretreatment blocked the ghrelin-induced rise in vasopressin secretion.
Peptide
GHRP-6
Outcome
DecreaseVasopressin secretion blockade
Study
ratn: not reported in source
Neurohypophyseal cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
The increase of vasopressin and oxytocin secretion could be totally blocked by previous administration of the ghrelin receptor antagonist ([D-Lys³]-growth hormone-releasing peptide-6).
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2775292805
06LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In rat neurohypophyseal cultures, the modified GHRP‑6 antagonist given before ghrelin completely blocked increased oxytocin secretion.
In plain wordsIn cells from rats, modified GHRP‑6 pretreatment blocked the ghrelin-induced rise in oxytocin secretion.
Peptide
GHRP-6
Outcome
DecreaseOxytocin secretion blockade
Study
ratn: not reported in source
Neurohypophyseal cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
The increase of vasopressin and oxytocin secretion could be totally blocked by previous administration of the ghrelin receptor antagonist ([D-Lys³]-growth hormone-releasing peptide-6).
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2775292806
07LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In rat neurohypophyseal cultures, the modified GHRP‑6 antagonist was ineffective when applied after ghrelin.
In plain wordsIn cells from rats, modified GHRP‑6 was ineffective when applied after ghrelin.
Peptide
GHRP-6
Outcome
No significant changeDelayed antagonist effect
Study
ratn: not reported in source
Neurohypophyseal cell cultures
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Application of the ghrelin receptor antagonist after ghrelin administration proved ineffective.
2 context sentences(design, population, supporting numbers)
Summary · context
The increase of vasopressin and oxytocin secretion could be totally blocked by previous administration of the ghrelin receptor antagonist ([D-Lys³]-growth hormone-releasing peptide-6).
Summary · context
The effects of ghrelin on vasopressin and oxytocin secretion were studied in 13-14-day cell cultures of isolated rat neurohypophyseal tissue.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2775292807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
9 Oct 2026, 03:13 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:49 UTC
First added · source update from Europe PMC

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