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Study · Not a test of the peptide alone · 2016

2 results

Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury.

Yang Y, Bai T, Yao YL, Zhang DQ, Wu YL, Lian LH, Nan JX

Toxicology letters26 Sept 2016Cited by 44 (Europe PMC)

PMID27688165 (opens in a new tab)DOI10.1016/j.toxlet.2016.09.014 (opens in a new tab)PepBankPUB-27688165
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hepatic stellate cells, AICAR pretreatment blocked TGF-β-induced attenuation of LKB1 phosphorylation.

    In plain wordsIn cells, AICAR prevented the reduction in LKB1 phosphorylation caused by TGF-β.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLKB1 phosphorylation
    Study

    n: not reported in source

    TGF-β-treated hepatic stellate cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    In vitro, TGF-β time-dependently attenuated liver kinase B-1 (LKB1) and AMPK phosphorylation, which were blocked by pretreatment with TQ and AICAR (an activator of AMPK).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hepatic stellate cells, AICAR pretreatment blocked TGF-β-induced attenuation of AMPK phosphorylation.

    In plain wordsIn cells, AICAR prevented the reduction in AMPK phosphorylation caused by TGF-β.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK phosphorylation
    Study

    n: not reported in source

    TGF-β-treated hepatic stellate cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    In vitro, TGF-β time-dependently attenuated liver kinase B-1 (LKB1) and AMPK phosphorylation, which were blocked by pretreatment with TQ and AICAR (an activator of AMPK).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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