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Study · Measured the body's own peptide · 2016

2 results

Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin.

Esaki H, Brunner PM, Renert-Yuval Y, Czarnowicki T, Huynh T, Tran G, Lyon S, Rodriguez G, Immaneni S, Johnson DB, Bauer B, Fuentes-Duculan J and 9 more

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Zheng X, Peng X, Estrada YD, Xu H, de Guzman Strong C, Suárez-Fariñas M, Krueger JG, Paller AS, Guttman-Yassky E

The Journal of allergy and clinical immunology23 Sept 2016Cited by 341 (Europe PMC)

PMID27671162 (opens in a new tab)DOI10.1016/j.jaci.2016.07.013 (opens in a new tab)PepBankPUB-27671162
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In lesional skin, children with early-onset atopic dermatitis had higher induction of LL37 than adults with atopic dermatitis.

    In plain wordsIn children with early atopic dermatitis, the body's own LL37 in affected skin was higher than in adults with the disease.

    Peptide
    LL-37
    Outcome
    IncreaseLL37 in lesional skin of children versus adults with AD
    Study

    n: not reported in source

    Comparator
    Adults with atopic dermatitis
    Outcome group
    Inflammation markers · Skin and wound

    Source sentences

    Summary
    Children showed significantly higher induction of TH17-related cytokines and antimicrobials (IL-17A, IL-19, CCL20, LL37, and peptidase inhibitor 3/elafin), TH9/IL-9, IL-33, and innate markers (IL-8) than adults (P < .02).
    1 context sentence
    Summary · context
    Using immunohistochemistry and quantitative real-time PCR, we assessed biopsy specimens from 19 children with AD younger than 5 years within 6 months of disease onset in comparison with adults with AD or psoriasis and pediatric and adult control subjects.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In nonlesional skin of children with atopic dermatitis, levels of inflammation markers including LL37 were higher than in comparison skin.

    In plain wordsIn children with atopic dermatitis, the body's own LL37 was higher in skin without lesions.

    Peptide
    LL-37
    Outcome
    IncreaseLL37 in nonlesional skin of children with AD
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Skin and wound

    Source sentences

    Summary
    Nonlesional skin in pediatric patients with AD showed higher levels of inflammation (particularly IL-17A and the related molecules IL-19 and LL37) and epidermal proliferation (keratin 16 and S100As) markers (P < .001).
    1 context sentence
    Summary · context
    Using immunohistochemistry and quantitative real-time PCR, we assessed biopsy specimens from 19 children with AD younger than 5 years within 6 months of disease onset in comparison with adults with AD or psoriasis and pediatric and adult control subjects.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:57 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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