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Study · Randomized controlled trial · n = 18 · 2016

4 results

Oxytocin modulates hemodynamic responses to monetary incentives in humans.

Mickey BJ, Heffernan J, Heisel C, Peciña M, Hsu DT, Zubieta JK, Love TM

Psychopharmacology10 Sept 2016Cited by 23 (Europe PMC)

PMID27614896 (opens in a new tab)PMCIDPMC5106343 (opens in a new tab)DOI10.1007/s00213-016-4423-6 (opens in a new tab)PepBankPUB-27614896
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin increased the BOLD signal in the midbrain during the late phase of the response to incentive stimuli versus placebo.

    In plain wordsIn healthy men, oxytocin increased activity in a reward-related brain area during a money task, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseMidbrain BOLD signal during incentive stimuli
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    We found that oxytocin increases the BOLD signal in the midbrain (substantia nigra and ventral tegmental area) during the late phase of the hemodynamic response to incentive stimuli.
    2 context sentences
    Summary · context
    We examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task.
    Summary · context
    The blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin.
  2. 02HumanRandomized controlled trialOther

    In healthy men, oxytocin effects on midbrain responses correlated positively with its effects on positive emotional state.

    In plain wordsIn healthy men, the oxytocin effect on a reward brain area matched its effect on positive mood.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of midbrain response with positive emotional state
    Study

    n = 18

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin's effects on midbrain responses correlated positively with its effects on positive emotional state.
    2 context sentences
    Summary · context
    We examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task.
    Summary · context
    The blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin.
  3. 03HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin had no detected effect on nucleus accumbens responses versus placebo.

    In plain wordsIn healthy men, oxytocin did not change activity in the nucleus accumbens compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeNucleus accumbens response to incentive stimuli
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    We did not detect an effect of oxytocin on responses in the nucleus accumbens.
    2 context sentences
    Summary · context
    We examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task.
    Summary · context
    The blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin.
  4. 04HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin attenuated medial prefrontal cortical deactivation during anticipation of loss versus placebo.

    In plain wordsIn healthy men, oxytocin reduced the drop in activity of a frontal brain area while expecting a loss, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseMedial prefrontal cortical deactivation during loss anticipation
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Whole-brain analyses revealed that oxytocin attenuated medial prefrontal cortical deactivation specifically during anticipation of loss.
    2 context sentences
    Summary · context
    We examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task.
    Summary · context
    The blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2Results postedNCT01722071

Deciphering the Role of Oxytocin in Motivation: an fMRI Study

Tiffany Loven = 20Oct 2012 to Oct 2015

Focus of Study: Neural Correlates of Oxytocin Administration

Trial pageClinicalTrials.govUpdated 29 Jan 2016

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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