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Study · Randomized controlled trial · n = 35 · 2017

2 results

Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder.

Nawijn L, van Zuiden M, Koch SB, Frijling JL, Veltman DJ, Olff M

Social cognitive and affective neuroscience1 Feb 2017Cited by 59 (Europe PMC)

PMID27614769 (opens in a new tab)PMCIDPMC5390752 (opens in a new tab)DOI10.1093/scan/nsw123 (opens in a new tab)PepBankPUB-27614769
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In police officers with PTSD, intranasal oxytocin increased left anterior insula responses to social reward versus placebo, so that patients no longer differed from controls under placebo.

    In plain wordsIn police officers with PTSD, oxytocin spray raised a brain response to social reward compared with placebo, to the level of controls.

    Peptide
    Oxytocin
    Outcome
    IncreaseLeft anterior insula response to social reward in PTSD
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin administration increased left AI responses during social reward in PTSD patients, such that PTSD patients no longer differed from controls under placebo.
    1 context sentence
    Summary · context
    Male and female police officers with (n = 35) and without PTSD (n = 37) were included in a double-blind, randomized, placebo-controlled cross-over fMRI study.
  2. 02HumanRandomized controlled trialMechanism

    In police officers with PTSD, intranasal oxytocin increased right putamen responses to social reward versus placebo.

    In plain wordsIn police officers with PTSD, oxytocin spray raised a brain response to social reward in the right putamen compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseRight putamen response to social reward in PTSD
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Furthermore, in PTSD patients, oxytocin increased responses to social reward in the right putamen.
    1 context sentence
    Summary · context
    Male and female police officers with (n = 35) and without PTSD (n = 37) were included in a double-blind, randomized, placebo-controlled cross-over fMRI study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT03211013

Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Palo Alto Veterans Institute for Researchn = 1710 Jul 2017 to 9 Jun 2021

Posttraumatic Stress Disorder

Trial pageClinicalTrials.govUpdated 10 Jun 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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