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Study · Animal study (in vivo) · rat · 2016

5 results

Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide.

Gorbacheva AM, Berdalin AB, Stulova AN, Nikogosova AD, Lin MD, Buravkov SV, Gavrilova SA, Koshelev VB

Bulletin of experimental biology and medicine1 Aug 2016

PMID27591879 (opens in a new tab)DOI10.1007/s10517-016-3442-y (opens in a new tab)PepBankPUB-27591879
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental myocardial infarction, Semax prevented the increase in the density of sympathetic endings in the caudal artery 28 days after ischemia or ischemia/reperfusion.

    In plain wordsIn rats with induced heart attack, Semax stopped the rise in sympathetic nerve endings in a tail artery.

    Peptide
    Semax
    Outcome
    DecreaseDensity of sympathetic endings in caudal artery
    Study

    ratn: not reported in source

    Experimental myocardial infarction (ischemia or ischemia/reperfusion)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax peptide moderated the degree of this activation and prevented the increase in the density of sympathetic endings in rat caudal artery in 28 days after ischemia or ischemia/reperfusion.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Semax reduced the density of α-adrenoreceptors in the caudal artery.

    In plain wordsIn rats with induced heart attack, Semax lowered the number of α-adrenoreceptors in a tail artery.

    Peptide
    Semax
    Outcome
    Decreaseα-adrenoreceptor density in caudal artery
    Study

    ratn: not reported in source

    Experimental myocardial infarction (ischemia or ischemia/reperfusion)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The peptide reduced the density of α-adrenoreceptors in the caudal artery of rats with myocardial infarction.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In both rat models of myocardial infarction, Semax had no effect on β-adrenoreceptors.

    In plain wordsIn rats with induced heart attack, Semax did not change β-adrenoreceptors in either model.

    Peptide
    Semax
    Outcome
    No significant changeβ-adrenoreceptor density in caudal artery
    Study

    ratn: not reported in source

    Experimental myocardial infarction (ischemia or ischemia/reperfusion)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax produced no effect on β-adrenoreceptors in both experimental models.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In isolated caudal artery segments from rats treated with Semax after ischemia/reperfusion injury, responsiveness to electrical stimulation was reduced.

    In plain wordsIn rats with induced heart attack, Semax treatment lowered the artery's response to electrical stimulation in isolated tissue.

    Peptide
    Semax
    Outcome
    DecreaseVascular responsiveness to electrical stimulation (isolated caudal artery)
    Study

    ratn: not reported in source

    Experimental myocardial infarction (ischemia or ischemia/reperfusion)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The experiments on isolated segments of the caudal artery revealed reduced vascular responsiveness to electrical stimulation and norepinephrine infusion in rats treated with Semax after ischemia/reperfusion injury.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In isolated caudal artery segments from rats treated with Semax after ischemia/reperfusion injury, responsiveness to norepinephrine infusion was reduced.

    In plain wordsIn rats with induced heart attack, Semax treatment lowered the artery's response to norepinephrine in isolated tissue.

    Peptide
    Semax
    Outcome
    DecreaseVascular responsiveness to norepinephrine infusion (isolated caudal artery)
    Study

    ratn: not reported in source

    Experimental myocardial infarction (ischemia or ischemia/reperfusion)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The experiments on isolated segments of the caudal artery revealed reduced vascular responsiveness to electrical stimulation and norepinephrine infusion in rats treated with Semax after ischemia/reperfusion injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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