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Study · Animal study (in vivo) · rat · 2016

3 results

Pharmacological Correction of Alcohol Motivation Depends on the Phenotype of the Response to Emotional Stress.

Kolik LG, Gudasheva TA, Martyanov VA, Seredenin SB

Bulletin of experimental biology and medicine1 Aug 2016

PMID27590755 (opens in a new tab)DOI10.1007/s10517-016-3449-4 (opens in a new tab)PepBankPUB-27590755
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In MR rats, GB‑115 significantly reduced average daily ethanol consumption.

    In plain wordsIn MR rats, GB‑115 significantly reduced average daily ethanol consumption.

    Peptide
    GB-115
    Outcome
    DecreaseAverage daily ethanol consumption
    Study

    ratn: not reported in source

    high-emotionality MR rats with long-term ethanol access
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    0.025 mg/kg · intraperitoneal · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    An anxiolytic GB-115 (0.025 mg/kg intraperitoneally for 14 days) with selective activity in high-emotionality rats was shown to reduce significantly the average daily consumption and alcohol-deprivation effect in MR rats, but did not modulate ethanol addiction in MNRA rats.
    2 context sentences
    Summary · context
    The specific features of alcohol behavior were studied in MR and MNRA rats that exhibit an opposite reaction to emotional stress.
    Summary · context
    We evaluated the effect of a dipeptide anxiolytic GB-115 (N-phenyl-hexanoyl-glycyl-L-tryptophan amide, neuropeptide cholecystokinin-4 analogue with antagonistic activity) on alcohol motivation in rats, which was formed over 12 months.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In MR rats, GB‑115 significantly reduced the alcohol-deprivation effect.

    In plain wordsIn MR rats, GB‑115 significantly reduced the alcohol-deprivation effect.

    Peptide
    GB-115
    Outcome
    DecreaseAlcohol-deprivation effect
    Study

    ratn: not reported in source

    high-emotionality MR rats with long-term ethanol access
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    0.025 mg/kg · intraperitoneal · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    An anxiolytic GB-115 (0.025 mg/kg intraperitoneally for 14 days) with selective activity in high-emotionality rats was shown to reduce significantly the average daily consumption and alcohol-deprivation effect in MR rats, but did not modulate ethanol addiction in MNRA rats.
    2 context sentences
    Summary · context
    The specific features of alcohol behavior were studied in MR and MNRA rats that exhibit an opposite reaction to emotional stress.
    Summary · context
    We evaluated the effect of a dipeptide anxiolytic GB-115 (N-phenyl-hexanoyl-glycyl-L-tryptophan amide, neuropeptide cholecystokinin-4 analogue with antagonistic activity) on alcohol motivation in rats, which was formed over 12 months.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In MNRA rats, GB‑115 did not modulate ethanol addiction.

    In plain wordsIn MNRA rats, GB‑115 did not change ethanol addiction.

    Peptide
    GB-115
    Outcome
    No significant changeEthanol addiction
    Study

    ratn: not reported in source

    low-emotionality MNRA rats with long-term ethanol access
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    0.025 mg/kg · intraperitoneal · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    An anxiolytic GB-115 (0.025 mg/kg intraperitoneally for 14 days) with selective activity in high-emotionality rats was shown to reduce significantly the average daily consumption and alcohol-deprivation effect in MR rats, but did not modulate ethanol addiction in MNRA rats.
    2 context sentences
    Summary · context
    The specific features of alcohol behavior were studied in MR and MNRA rats that exhibit an opposite reaction to emotional stress.
    Summary · context
    We evaluated the effect of a dipeptide anxiolytic GB-115 (N-phenyl-hexanoyl-glycyl-L-tryptophan amide, neuropeptide cholecystokinin-4 analogue with antagonistic activity) on alcohol motivation in rats, which was formed over 12 months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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