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Study · Systematic review · 2017

4 results

Oxytocin and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ooi YP, Weng SJ, Kossowsky J, Gerger H, Sung M

Pharmacopsychiatry30 Aug 2016Cited by 88 (Europe PMC)

PMID27574858 (opens in a new tab)DOI10.1055/s-0042-109400 (opens in a new tab)PepBankPUB-27574858
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a meta-analysis of randomized trials in autism spectrum disorder, oxytocin had no significant effect on social cognition.

    In plain wordsIn people with autism, a pooled analysis of trials found no significant effect of oxytocin on social cognition.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial cognition (meta-analysis)
    Study

    n: not reported in source

    Outcome group
    Autism core symptoms · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, results from our meta-analyses suggest that oxytocin has no significant effect on these 2 domains.
    1 context sentence
    Summary · context
    12 RCTs were included in this review.
  2. 02HumanSystematic reviewEfficacy outcome

    In a meta-analysis of randomized trials in autism spectrum disorder, oxytocin had no significant effect on restricted, repetitive behaviors.

    In plain wordsIn people with autism, a pooled analysis of trials found no significant effect of oxytocin on restricted, repetitive behaviors.

    Peptide
    Oxytocin
    Outcome
    No significant changeRestricted, repetitive behaviors (meta-analysis)
    Study

    n: not reported in source

    Outcome group
    Autism core symptoms · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, results from our meta-analyses suggest that oxytocin has no significant effect on these 2 domains.
    1 context sentence
    Summary · context
    12 RCTs were included in this review.
  3. 03HumanSystematic reviewEfficacy outcome

    In a systematic review of 12 randomized trials in autism spectrum disorder, 7 of 11 studies that examined social cognition reported improvements with oxytocin.

    In plain wordsIn people with autism, 7 of 11 trials on social cognition reported improvements with oxytocin, but the pooled analysis found no significant effect.

    Peptide
    Oxytocin
    Outcome
    MixedSocial cognition (individual study results)
    Study

    n: not reported in source

    Outcome group
    Autism core symptoms · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    7 out of the 11 studies that examined social cognition reported improvements.
    1 context sentence
    Summary · context
    12 RCTs were included in this review.
  4. 04HumanSystematic reviewEfficacy outcome

    In a systematic review of 12 randomized trials in autism spectrum disorder, one of 4 studies on restricted, repetitive behaviors reported improvements following oxytocin.

    In plain wordsIn people with autism, one of 4 trials on restricted, repetitive behaviors reported improvements with oxytocin, but the pooled analysis found no significant effect.

    Peptide
    Oxytocin
    Outcome
    MixedRestricted, repetitive behaviors (individual study results)
    Study

    n: not reported in source

    Outcome group
    Autism core symptoms · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, one out of the 4 studies on restricted, repetitive behaviors, reported improvements following oxytocin administration.
    1 context sentence
    Summary · context
    12 RCTs were included in this review.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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