Skip to content

Study · Measured the body's own peptide · 2016

1 result

Regulation of myoglobin in hypertrophied rat cardiomyocytes in experimental pulmonary hypertension.

Peters EL, Offringa C, Kos D, Van der Laarse WJ, Jaspers RT

Pflugers Archiv : European journal of physiology30 Aug 2016Cited by 5 (Europe PMC)

PMID27572699 (opens in a new tab)PMCIDPMC5026723 (opens in a new tab)DOI10.1007/s00424-016-1865-y (opens in a new tab)PepBankPUB-27572699
Download PDFPubMedAsk about this study
Jump to 1 result

Summary

A major problem in chronic heart failure is the inability of hypertrophied cardiomyocytes to maintain the required power output. A Hill-type oxygen diffusion model predicts that oxygen supply is limiting in hypertrophied cardiomyocytes at maximal rates of oxygen consumption and that this limitation can be reduced by increasing the myoglobin (Mb) concentration. We explored how cardiac hypertrophy, oxidative capacity, and Mb expression in right ventricular cardiomyocytes are regulated at the transcriptional and translational levels in an early stage of experimental pulmonary hypertension, in order to identify targets to improve the oxygen supply/demand ratio. Male Wistar rats were injected with monocrotaline to induce pulmonary hypertension (PH) and right ventricular heart failure. The messenger RNA (mRNA) expression levels per nucleus of growth factors insulin-like growth factor-1Ea (IGF-1Ea) and mechano growth factor (MGF) were higher in PH than in healthy controls, consistent with a doubling in cardiomyocyte cross-sectional area (CSA). Succinate dehydrogenase (SDH) activity was unaltered, indicating that oxidative capacity per cell increased. Although the Mb protein concentration was unchanged, Mb mRNA concentration was reduced. However, total RNA per nucleus was about threefold higher in PH rats versus controls, and Mb mRNA content expressed per nucleus was similar in the two groups. The increase in oxidative capacity without an increase in oxygen supply via Mb-facilitated diffusion caused a doubling of the critical extracellular oxygen tension required to prevent hypoxia (PO2crit). We conclude that Mb mRNA expression is not increased during pressure overload-induced right ventricular hypertrophy and that the increase in myoglobin content per myocyte is likely due to increased translation. We conclude that increasing Mb mRNA expression may be beneficial in the treatment of experimental PH.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats with monocrotaline-induced pulmonary hypertension, the body's own MGF mRNA per nucleus in right ventricular cardiomyocytes was higher than in healthy controls.

    In plain wordsIn rats with pulmonary hypertension, the body's own MGF gene activity in heart muscle cells was higher than in healthy rats.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA expression per nucleus
    Study

    ratn: not reported in source

    Monocrotaline-induced pulmonary hypertension, right ventricular cardiomyocytes
    Comparator
    Healthy controls
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    The messenger RNA (mRNA) expression levels per nucleus of growth factors insulin-like growth factor-1Ea (IGF-1Ea) and mechano growth factor (MGF) were higher in PH than in healthy controls, consistent with a doubling in cardiomyocyte cross-sectional area (CSA).
    2 context sentences
    Summary · context
    We explored how cardiac hypertrophy, oxidative capacity, and Mb expression in right ventricular cardiomyocytes are regulated at the transcriptional and translational levels in an early stage of experimental pulmonary hypertension, in order to identify targets to improve the oxygen supply/demand ratio.
    Summary · context
    Male Wistar rats were injected with monocrotaline to induce pulmonary hypertension (PH) and right ventricular heart failure.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.