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Study · In vitro (cells) · 2016

3 results

Possible role of the Ec peptide of IGF‑1Ec in cartilage repair.

Armakolas N, Dimakakos A, Armakolas A, Antonopoulos A, Koutsilieris M

Molecular medicine reports12 Aug 2016Cited by 10 (Europe PMC)

PMID27571686 (opens in a new tab)PMCIDPMC5042773 (opens in a new tab)DOI10.3892/mmr.2016.5627 (opens in a new tab)PepBankPUB-27571686
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human mesenchymal stem cells, the Ec peptide (PEc) was involved in differentiation toward hyaline cartilage.

    In plain wordsIn cells, the Ec peptide took part in turning stem cells toward cartilage.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableDifferentiation of hMSCs toward hyaline cartilage
    Study

    humann: not reported in source

    Human mesenchymal stem cells (hMSCs)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was determined that PEc is involved in the differentiation process of hMSCs towards hyaline cartilage.
    1 context sentence
    Summary · context
    The effects of the exogenous administration of PEc and TGF‑β1, alone and in combination, on hMSCs were assessed using a trypan blue assay, reverse transcription-quantitative polymerase chain reaction, western blot analysis, Alcian blue staining, wound healing assays and migration/invasion assays.

Studies that did not test the peptide alone2

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 02LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome

    In human mesenchymal stem cells, PEc, TGF-β1 or both together gave comparable cartilage matrix deposition.

    In plain wordsIn cells, the Ec peptide, TGF-β1, or both gave similar cartilage matrix deposition.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeCartilage matrix deposition
    Study

    humann: not reported in source

    Human mesenchymal stem cells (hMSCs)
    Comparator
    PEc, TGF-β1 and PEc plus TGF-β1 compared with each other
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Treatment of hMSCs with either PEc, TGF‑β1 or both, demonstrated comparable cartilage matrix deposition.
    1 context sentence
    Summary · context
    The effects of the exogenous administration of PEc and TGF‑β1, alone and in combination, on hMSCs were assessed using a trypan blue assay, reverse transcription-quantitative polymerase chain reaction, western blot analysis, Alcian blue staining, wound healing assays and migration/invasion assays.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 03LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome

    In human mesenchymal stem cells, PEc combined with TGF-β1 increased cell mobilization significantly more than TGF-β1 alone or PEc alone.

    In plain wordsIn cells, the Ec peptide with TGF-β1 moved stem cells more than TGF-β1 alone or the peptide alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreasehMSC mobilization with PEc plus TGF-β1
    Study

    humann: not reported in source

    Human mesenchymal stem cells (hMSCs)
    Comparator
    TGF-β1 alone or PEc alone
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Furthermore, treatment with PEc in combination with TGF‑β1 was associated with a significant increase in hMSC mobilization when compared with treatment with TGF‑β1 or PEc alone (P<0.05).
    1 context sentence
    Summary · context
    The effects of the exogenous administration of PEc and TGF‑β1, alone and in combination, on hMSCs were assessed using a trypan blue assay, reverse transcription-quantitative polymerase chain reaction, western blot analysis, Alcian blue staining, wound healing assays and migration/invasion assays.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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