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Study · Animal study (in vivo) · mouse · 2016

2 results

Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.

Viennois E, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang M, Han MK, Garg P, Xiao B, Merlin D

Cellular and molecular gastroenterology and hepatology1 May 2016Cited by 27 (Europe PMC)

PMID27458604 (opens in a new tab)PMCIDPMC4957955 (opens in a new tab)DOI10.1016/j.jcmgh.2016.01.006 (opens in a new tab)PepBankPUB-27458604
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with AOM/DSS-induced colitis-associated cancer, KPV prevented carcinogenesis.

    In plain wordsIn mice, KPV helped prevent tumours that arise from long-term gut inflammation.

    Peptide
    KPV
    Outcome
    DecreaseColitis-associated tumorigenesis
    Study

    mousen: not reported in source

    AOM/DSS-induced colitis-associated cancer
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The use of an anti-inflammatory tripeptide KPV (Lys-Pro-Val) transported by PepT1 was able to prevent carcinogenesis in WT mice.
    1 context sentence
    Summary · context
    Mice with hPepT1 overexpression in intestinal epithelial cells (TG) or PepT1 (PepT1-KO) deletion were used and CAC was induced by AOM/DSS.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In PepT1-knockout mice, KPV did not trigger the inhibitory effect on tumorigenesis seen in wild-type mice.

    In plain wordsIn mice that lack the PepT1 transporter, KPV did not reduce tumour development as it did in normal mice.

    Peptide
    KPV
    Outcome
    No significant changeColitis-associated tumorigenesis in PepT1-KO mice
    Study

    mousen: not reported in source

    AOM/DSS-induced colitis-associated cancer
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When administered to PepT1-KO mice, KPV did not trigger any of the inhibitory effect on tumorigenesis observed in WT mice.
    1 context sentence
    Summary · context
    Mice with hPepT1 overexpression in intestinal epithelial cells (TG) or PepT1 (PepT1-KO) deletion were used and CAC was induced by AOM/DSS.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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