Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid.

Calderón Guzmán D, Brizuela NO, Ortíz Herrera M, Hernández García E, Barragán Mejía G, Juárez Olguín H, Valenzuela Peraza A, Attilus J, Labra Ruíz N

Acta pharmaceutica (Zagreb, Croatia)1 Sept 2016Cited by 6 (Europe PMC)

PMID27383892DOI10.1515/acph-2016-0027PepBankPUB-27383892

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased cortex dopamine levels.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased dopamine levels in the cortex.
Peptide
Cerebrolysin
Outcome
DecreaseCortex dopamine
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389201
02AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased dopamine levels in the hemispheres.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased dopamine levels in the hemispheres.
Peptide
Cerebrolysin
Outcome
DecreaseHemispheres dopamine
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389202
03AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased dopamine levels in the cerebellum/medulla oblongata.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased dopamine levels in the cerebellum/medulla oblongata.
Peptide
Cerebrolysin
Outcome
DecreaseCerebellum/medulla oblongata dopamine
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389203
04AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased cortex lipid peroxidation.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased lipid peroxidation in the cortex.
Peptide
Cerebrolysin
Outcome
DecreaseCortex lipid peroxidation
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389204
05AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased lipid peroxidation in the hemispheres.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased lipid peroxidation in the hemispheres.
Peptide
Cerebrolysin
Outcome
DecreaseHemispheres lipid peroxidation
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389205
06AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased lipid peroxidation in the cerebellum/medulla oblongata.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased lipid peroxidation in the cerebellum/medulla oblongata.
Peptide
Cerebrolysin
Outcome
DecreaseCerebellum/medulla oblongata lipid peroxidation
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389206
07AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased calcium levels in the hemispheres.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased calcium levels in the hemispheres.
Peptide
Cerebrolysin
Outcome
DecreaseHemispheres calcium
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389207
08AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin decreased H2O2 levels in the hemispheres.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin decreased H2O2 levels in the hemispheres.
Peptide
Cerebrolysin
Outcome
DecreaseHemispheres H2O2
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389208
09AnimalAnimal study (in vivo)Mechanism
In rats treated with 3-NPA, Cerebrolysin increased cortex GSH levels.
In plain wordsIn rats treated with 3-NPA, Cerebrolysin increased GSH levels in the cortex.
Peptide
Cerebrolysin
Outcome
IncreaseCortex GSH
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389209
10AnimalAnimal study (in vivo)Mechanism
In rats, Cerebrolysin increased dopamine metabolism, particularly under the 3-NPA challenge.
In plain wordsIn rats, Cerebrolysin increased dopamine metabolism, especially under the 3-NPA challenge.
Peptide
Cerebrolysin
Outcome
IncreaseDopamine metabolism
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389210
11AnimalAnimal study (in vivo)Mechanism
In rats, Cerebrolysin increased radical species formation, especially when 3-NPA generated free radicals.
In plain wordsIn rats, Cerebrolysin increased radical species formation, especially when 3-NPA generated free radicals.
Peptide
Cerebrolysin
Outcome
IncreaseRadical species formation
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389211
12AnimalAnimal study (in vivo)Mechanism
In rats, Cerebrolysin increased oxidative stress, especially when 3-NPA generated free radicals.
In plain wordsIn rats, Cerebrolysin increased oxidative stress, especially when 3-NPA generated free radicals.
Peptide
Cerebrolysin
Outcome
IncreaseOxidative stress
Study
ratn: not reported in source
Young male Fischer rats treated with 3-NPA
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · three daysAs given in this study (rat).
Source sentences
Summary
The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA.
2 context sentences(design, population, supporting numbers)
Summary · context
Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances.
Summary · context
Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods.
Report a problemFND-2738389212

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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