Magel2-null mice were hypersensitive to setmelanotide's appetite-suppressing and metabolic effects; the abstract provides no separate outcome results or explicit comparator.
In plain wordsIn Magel2-null mice, sensitivity to setmelanotide's appetite-suppressing and metabolic effects was high; the abstract gives no explicit comparator.
- Peptide
- Setmelanotide
- Outcome
- Direction not reportedSensitivity to appetite suppression and metabolic effects
- Study
mousen: not reported in source
Magel2-null mice- Outcome group
- Appetite and food intake · Metabolic and weight
- Studied dose
- Dose not stated
Source sentences
We show that Magel2-null mice are hypersensitive to the appetite suppressing and metabolic effects of setmelanotide.
1 context sentence(design, population, supporting numbers)
We tested a dose titration of the MC4 receptor agonist setmelanotide, in development for rare monogenic forms of obesity, in Magel2-null mice.