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Study · Not a test of the peptide alone · 2016

4 results

Mechano-growth factor E peptide promotes healing of rat injured tendon.

Zhang B, Luo Q, Kuang D, Ju Y, Song G

Biotechnology letters22 Jun 2016Cited by 5 (Europe PMC)

PMID27334712 (opens in a new tab)DOI10.1007/s10529-016-2162-8 (opens in a new tab)PepBankPUB-27334712
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon injury, the MGF fragment MGF-C25E significantly increased the Achilles functional index compared with saline.

    In plain wordsIn rats with injured tendons, an MGF fragment improved the Achilles functional index more than saline.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseAchilles functional index
    Study

    ratn: not reported in source

    rat Achilles tendon injury
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal

    Source sentences

    Summary
    A significantly increased Achilles functional index was found in the MGF-C25E-treated tendons relative to the saline-treated tendons.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon injury, macroscopic repair was superior in MGF-C25E-treated tendons than in saline-treated tendons.

    In plain wordsIn rats with injured tendons, tendons treated with an MGF fragment looked better repaired than those treated with saline.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMacroscopic tendon repair
    Study

    ratn: not reported in source

    rat Achilles tendon injury
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal

    Source sentences

    Summary
    Macroscopic observation showed that the repair of MGF-C25E-treated (1000 ng/ml) tendons was superior to that of the saline-treated tendons.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 03AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon injury, MGF-C25E significantly increased the stiffness of repaired tendons compared with saline.

    In plain wordsIn rats with injured tendons, an MGF fragment made repaired tendons stiffer than saline did.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseStiffness of repaired tendons
    Study

    ratn: not reported in source

    rat Achilles tendon injury
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal

    Source sentences

    Summary
    The mean value of the stiffness of the repaired tendons was significantly increased in the MGF-C25E-treated (1000 ng/ml) tendons relative to the saline-treated tendons.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  4. 04AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon injury, histological analysis provided evidence of tissue remodeling and cell alignment.

    In plain wordsIn rats with injured tendons, tissue samples showed remodeling and cell alignment.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseHistological tissue remodeling and cell alignment
    Study

    ratn: not reported in source

    rat Achilles tendon injury
    Outcome group
    Tendon and ligament healing · Musculoskeletal

    Source sentences

    Summary
    Moreover, histological analysis provided evidence of tissue remodeling and cell alignment.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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