Skip to content

Study · In vitro (cells) · mouse · 2016

2 results

Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model.

Antipova TA, Nikolaev SV, Ostrovskaya PU, Gudasheva TA, Seredenin SB

Bulletin of experimental biology and medicine1 May 2016

PMID27265136 (opens in a new tab)DOI10.1007/s10517-016-3344-z (opens in a new tab)PepBankPUB-27265136
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In mouse HT-22 neurons, Noopept before or after glutamic acid improved neuronal survival.

    In plain wordsIn cells from mouse hippocampus, Noopept before or after glutamic acid improved neuronal survival.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseNeuronal survival
    Study

    mousen: not reported in source

    Immortalized hippocampal HT-22 neurons exposed to glutamic acid
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10-11-10-5 MAs given in this study (mouse).

    Source sentences

    Summary
    Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M.
    1 context sentence
    Summary · context
    Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons.
  2. 02LabIn vitro (cells)Efficacy outcome

    Comparison with previous studies indicated that mouse hippocampal neurons were more sensitive to Noopept protection than cultured cortical and cerebellar neurons.

    In plain wordsIn cells, hippocampal neurons showed greater sensitivity to Noopept protection than cortical and cerebellar neurons studied previously.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseRelative neuronal sensitivity to Noopept protection
    Study

    mousen: not reported in source

    Immortalized hippocampal HT-22 neurons exposed to glutamic acid
    Comparator
    Cultured cortical and cerebellar neurons from previous studies
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Comparison of the effective noopept concentrations determined in previous studies on cultured cortical and cerebellar neurons showed that hippocampal neurons are more sensitive to the protective effect of noopept.
    1 context sentence
    Summary · context
    Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.