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Study · Not a test of the peptide alone · 2016

1 result

Toll-like receptor 4 knockout alleviates paraquat-induced cardiomyocyte contractile dysfunction through an autophagy-dependent mechanism.

Wang S, Zhu X, Xiong L, Zhang Y, Ren J

Toxicology letters28 May 2016Cited by 24 (Europe PMC)

PMID27246695 (opens in a new tab)DOI10.1016/j.toxlet.2016.05.024 (opens in a new tab)PepBankPUB-27246695
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In cardiomyocytes, AICAR negated the mechanical protection from TLR4 inhibition against paraquat toxicity.

    In plain wordsIn cells, AICAR removed the protection from TLR4 inhibition against paraquat-related mechanical damage.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardioprotection from TLR4 inhibition
    Study

    n: not reported in source

    Cardiomyocytes
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    In vitro study revealed that AMPK activation using AICAR or mTOR inhibition using rapamycin effectively negated the beneficial cardiomyocyte mechanical effects of TLR4 inhibition (CLI-095) against paraquat toxicity, supporting a permissive role for AMPK-mTOR in TLR4 inhibition-offered cardioprotection against paraquat.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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