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Study · Randomized controlled trial · n = 62 · 2017

2 results

The role of oxytocin in empathy in PTSD.

Palgi S, Klein E, Shamay-Tsoory S

Psychological trauma : theory, research, practice and policy30 May 2016Cited by 24 (Europe PMC)

PMID27243570 (opens in a new tab)DOI10.1037/tra0000142 (opens in a new tab)PepBankPUB-27243570
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with PTSD and healthy controls, intranasal oxytocin did not improve empathic abilities versus placebo.

    In plain wordsIn people with PTSD and healthy people, oxytocin spray did not improve empathy compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmotional and cognitive empathy after oxytocin
    Study

    n = 62

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    The administration of OT did not improve empathic abilities in our sample
    1 context sentence
    Summary · context
    Using a randomized, double-blind, placebo-controlled crossover design, we administered 24 International Units of oxytocin and placebo at a 1-week interval to 32 patients with PTSD and to 30 matched healthy controls and then measured participants' emotional and cognitive empathy.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In men with PTSD, intranasal oxytocin tended to enhance the recognition of angry body motions versus placebo.

    In plain wordsIn men with PTSD, oxytocin spray tended to improve recognition of angry body movements compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeRecognition of anger body motions in men with PTSD
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    although it did tend to selectively enhance the ability of men with PTSD to recognize body motions of anger.
    1 context sentence
    Summary · context
    Using a randomized, double-blind, placebo-controlled crossover design, we administered 24 International Units of oxytocin and placebo at a 1-week interval to 32 patients with PTSD and to 30 matched healthy controls and then measured participants' emotional and cognitive empathy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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