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Study · Animal study (in vivo) · mouse · 2016

5 results

Frequency of Teriparatide Administration Affects the Histological Pattern of Bone Formation in Young Adult Male Mice.

Yamamoto T, Hasegawa T, Sasaki M, Hongo H, Tsuboi K, Shimizu T, Ota M, Haraguchi M, Takahata M, Oda K, Luiz de Freitas PH, Takakura A, Takao-Kawabata R, Isogai Y, Amizuka N

Endocrinology26 May 2016Cited by 52 (Europe PMC)

PMID27227535 (opens in a new tab)DOI10.1210/en.2015-2028 (opens in a new tab)PepBankPUB-27227535
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, high-frequency teriparatide increased metaphyseal trabecular number with the per-injection regimen.

    In plain wordsIn mice, frequent teriparatide injections increased the number of bone trabeculae.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMetaphyseal trabecular number
    Study

    micen: not reported in source

    Young adult male mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    80 μg/kg per injectionAs given in this study (mice).

    Source sentences

    Summary
    With the regimens of 80 μg/kg per dose and 80 μg/kg · d, high-frequency hPTH(1-34) administration increased metaphyseal trabecular number.
    2 context sentences
    Summary · context
    To investigate that issue, mice were subjected to different frequencies of PTH administration, and their bones were histologically examined.
    Summary · context
    Mice were allocated to either to control or to 3 different dosing regimens: 80 μg/kg of hPTH(1-34) per injection (80 μg/kg per dose), 80 μg/kg of hPTH(1-34) per day (80 μg/kg · d), or 20 μg/kg of hPTH(1-34) per day (20 μg/kg · d).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, high-frequency teriparatide increased metaphyseal trabecular number with the daily-total regimen.

    In plain wordsIn mice, frequent teriparatide doses increased the number of bone trabeculae.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMetaphyseal trabecular number
    Study

    micen: not reported in source

    Young adult male mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    80 μg/kg per dayAs given in this study (mice).

    Source sentences

    Summary
    With the regimens of 80 μg/kg per dose and 80 μg/kg · d, high-frequency hPTH(1-34) administration increased metaphyseal trabecular number.
    2 context sentences
    Summary · context
    To investigate that issue, mice were subjected to different frequencies of PTH administration, and their bones were histologically examined.
    Summary · context
    Mice were allocated to either to control or to 3 different dosing regimens: 80 μg/kg of hPTH(1-34) per injection (80 μg/kg per dose), 80 μg/kg of hPTH(1-34) per day (80 μg/kg · d), or 20 μg/kg of hPTH(1-34) per day (20 μg/kg · d).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, four daily teriparatide doses formed thin trabeculae, whereas daily dosing formed thicker trabeculae.

    In plain wordsIn mice, frequent teriparatide dosing formed thinner bone trabeculae than daily dosing.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseTrabecular thickness
    Study

    micen: not reported in source

    Young adult male mice
    Comparator
    Daily PTH regimen
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, 4 doses per day induced the formation of thin trabeculae, whereas the daily PTH regimen resulted in thicker trabeculae.
    2 context sentences
    Summary · context
    To investigate that issue, mice were subjected to different frequencies of PTH administration, and their bones were histologically examined.
    Summary · context
    Mice were allocated to either to control or to 3 different dosing regimens: 80 μg/kg of hPTH(1-34) per injection (80 μg/kg per dose), 80 μg/kg of hPTH(1-34) per day (80 μg/kg · d), or 20 μg/kg of hPTH(1-34) per day (20 μg/kg · d).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, more frequent low-dose teriparatide formed thin trabeculae with histological signs of accelerated remodeling.

    In plain wordsIn mice, frequent low-dose teriparatide formed thin bone trabeculae with signs of faster bone remodeling.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    MixedTrabecular thickness and remodeling pattern
    Study

    micen: not reported in source

    Young adult male mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 μg/kg per dayAs given in this study (mice).

    Source sentences

    Summary
    A similar pattern was observed with the lower daily hPTH(1-34) dose (20 μg/kg · d): more frequent PTH administration led to the formation of thin trabeculae, showing a thick preosteoblastic cell layer, several osteoclasts, and scalloped cement lines that indicated accelerated bone remodeling.
    2 context sentences
    Summary · context
    To investigate that issue, mice were subjected to different frequencies of PTH administration, and their bones were histologically examined.
    Summary · context
    Mice were allocated to either to control or to 3 different dosing regimens: 80 μg/kg of hPTH(1-34) per injection (80 μg/kg per dose), 80 μg/kg of hPTH(1-34) per day (80 μg/kg · d), or 20 μg/kg of hPTH(1-34) per day (20 μg/kg · d).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, low-frequency teriparatide induced new bone with mature osteoblasts and surfaces suggesting minimodeling-based formation.

    In plain wordsIn mice, infrequent teriparatide dosing formed new bone with mature bone-forming cells.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableMinimodeling bone formation
    Study

    micen: not reported in source

    Young adult male mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, low-frequency PTH administration induced new bone with mature osteoblasts lying on mildly convex surfaces representative of arrest lines, which suggests minimodeling-based bone formation.
    2 context sentences
    Summary · context
    To investigate that issue, mice were subjected to different frequencies of PTH administration, and their bones were histologically examined.
    Summary · context
    Mice were allocated to either to control or to 3 different dosing regimens: 80 μg/kg of hPTH(1-34) per injection (80 μg/kg per dose), 80 μg/kg of hPTH(1-34) per day (80 μg/kg · d), or 20 μg/kg of hPTH(1-34) per day (20 μg/kg · d).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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