Teriparatide Improves Fracture Healing and Early Functional Recovery in Treatment of Osteoporotic Intertrochanteric Fractures.

Huang TW, Chuang PY, Lin SJ, Lee CY, Huang KC, Shih HN, Lee MS, Hsu RW, Shen WJ

Medicine1 May 2016Cited by 46 (Europe PMC)

PMID27175673PMCIDPMC4902515DOI10.1097/md.0000000000003626PepBankPUB-27175673

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanObservational studyEfficacy outcome
In osteoporotic intertrochanteric fractures, teriparatide-treated groups had shorter union times than controls, with means of 12.3 and 10.6 versus 13.6 weeks.
In plain wordsIn hip fractures, teriparatide treatment was linked to faster bone union than calcium and vitamin D alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseTime to union
Study
n = 189
Comparator
Calcium and vitamin D without teriparatide
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Measurements
Mean time to union
13.6 weeks
Group 1, calcium and vitamin D only
Mean time to union
12.3 weeks
Group 2, teriparatide plus calcium and vitamin D
Mean time to union
10.6 weeks
Group 3, teriparatide after prior alendronate
Source sentences
Summary
A significantly shorter time-to-union was found in the teriparatide-treated groups (mean, 13.6, 12.3, and 10.6 weeks, respectively [P = 0.002]).
3 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to assess whether teriparatide accelerates fracture healing.Between 2008 and 2014, patients with osteoporotic intertrochanteric fractures who underwent surgical interventions were enrolled in this retrospective cohort study.
Summary · context
Group 1 included patients who were not on any osteoporosis medication prior to fracture and who postoperatively received only calcium and vitamin D; patients in Group 2 were not on any osteoporosis medication prior to fracture, and received teriparatide and calcium and vitamin D postoperatively.
Summary · context
Patients in Group 3 were those who were on alendronate prior to fracture and postfracture received teriparatide as well as calcium and vitamin D.
Report a problemFND-2717567301
02HumanObservational studyEfficacy outcome
In osteoporotic intertrochanteric fractures, teriparatide-treated groups had better physical component scores than controls at 3 and 6 months.
In plain wordsIn hip fractures, teriparatide treatment was linked to better physical health scores than calcium and vitamin D alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSF-12 physical component score
Study
n = 189
Comparator
Calcium and vitamin D without teriparatide
Outcome group
Quality of life · Musculoskeletal
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Measurements
SF-12 PCS mean score
19 points
Group 1, 3 months
SF-12 PCS mean score
28 points
Group 2, 3 months
SF-12 PCS mean score
29 points
Group 3, 3 months
SF-12 PCS mean score
28 points
Group 1, 6 months
SF-12 PCS mean score
37 points
Group 2, 6 months
SF-12 PCS mean score
38 points
Group 3, 6 months
Source sentences
Summary
With regard to SF-12 PCS, the scores were significantly better in teriparatide-treated groups at 3 months (mean, 19, 28, and 29, respectively [P = 0.002]) and 6 months (mean, 28, 37, and 38, respectively [P = 0.008]).
3 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to assess whether teriparatide accelerates fracture healing.Between 2008 and 2014, patients with osteoporotic intertrochanteric fractures who underwent surgical interventions were enrolled in this retrospective cohort study.
Summary · context
Group 1 included patients who were not on any osteoporosis medication prior to fracture and who postoperatively received only calcium and vitamin D; patients in Group 2 were not on any osteoporosis medication prior to fracture, and received teriparatide and calcium and vitamin D postoperatively.
Summary · context
Patients in Group 3 were those who were on alendronate prior to fracture and postfracture received teriparatide as well as calcium and vitamin D.
Report a problemFND-2717567302
03HumanObservational studyEfficacy outcome
In osteoporotic intertrochanteric fractures, teriparatide-treated groups had better pain scores than controls at 3 and 6 months.
In plain wordsIn hip fractures, teriparatide treatment was linked to less pain than calcium and vitamin D alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreasePain score
Study
n = 189
Comparator
Calcium and vitamin D without teriparatide
Outcome group
Pain · Musculoskeletal
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
Similar inter-group differences were noted when comparing the pain scores, the ability to get around the house, the ability to get out of the house, and the ability to go shopping at 3 and 6 months.
3 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to assess whether teriparatide accelerates fracture healing.Between 2008 and 2014, patients with osteoporotic intertrochanteric fractures who underwent surgical interventions were enrolled in this retrospective cohort study.
Summary · context
Group 1 included patients who were not on any osteoporosis medication prior to fracture and who postoperatively received only calcium and vitamin D; patients in Group 2 were not on any osteoporosis medication prior to fracture, and received teriparatide and calcium and vitamin D postoperatively.
Summary · context
Patients in Group 3 were those who were on alendronate prior to fracture and postfracture received teriparatide as well as calcium and vitamin D.
Report a problemFND-2717567303
04HumanObservational studyEfficacy outcome
In osteoporotic intertrochanteric fractures, teriparatide-treated groups showed similar inter-group differences favouring teriparatide in the ability to get around the house, get out of the house and go shopping at 3 and 6 months.
In plain wordsIn hip fractures, teriparatide-treated groups were linked to better daily-activity scores than calcium and vitamin D alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAbility to get around the house, get out of the house and go shopping
Study
n = 189
Comparator
Calcium and vitamin D without teriparatide
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
Similar inter-group differences were noted when comparing the pain scores, the ability to get around the house, the ability to get out of the house, and the ability to go shopping at 3 and 6 months.
3 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to assess whether teriparatide accelerates fracture healing.Between 2008 and 2014, patients with osteoporotic intertrochanteric fractures who underwent surgical interventions were enrolled in this retrospective cohort study.
Summary · context
Group 1 included patients who were not on any osteoporosis medication prior to fracture and who postoperatively received only calcium and vitamin D; patients in Group 2 were not on any osteoporosis medication prior to fracture, and received teriparatide and calcium and vitamin D postoperatively.
Summary · context
Patients in Group 3 were those who were on alendronate prior to fracture and postfracture received teriparatide as well as calcium and vitamin D.
Report a problemFND-2717567304
05HumanObservational studySafety outcome
In osteoporotic intertrochanteric fractures, complications were lower in teriparatide-treated groups than controls.
In plain wordsIn hip fractures, teriparatide treatment was linked to fewer complications than calcium and vitamin D alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseComplications
Study
n = 189
Comparator
Calcium and vitamin D without teriparatide
Outcome group
Adverse events · Whole body
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
Complications and mortality were also markedly reduced in the teriparatide-treated groups.
3 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to assess whether teriparatide accelerates fracture healing.Between 2008 and 2014, patients with osteoporotic intertrochanteric fractures who underwent surgical interventions were enrolled in this retrospective cohort study.
Summary · context
Group 1 included patients who were not on any osteoporosis medication prior to fracture and who postoperatively received only calcium and vitamin D; patients in Group 2 were not on any osteoporosis medication prior to fracture, and received teriparatide and calcium and vitamin D postoperatively.
Summary · context
Patients in Group 3 were those who were on alendronate prior to fracture and postfracture received teriparatide as well as calcium and vitamin D.
Report a problemFND-2717567305
06HumanObservational studySafety outcome
In osteoporotic intertrochanteric fractures, mortality was lower in teriparatide-treated groups than controls.
In plain wordsIn hip fractures, teriparatide treatment was linked to fewer deaths than calcium and vitamin D alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseMortality
Study
n = 189
Comparator
Calcium and vitamin D without teriparatide
Outcome group
Mortality · Whole body
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
Complications and mortality were also markedly reduced in the teriparatide-treated groups.
3 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to assess whether teriparatide accelerates fracture healing.Between 2008 and 2014, patients with osteoporotic intertrochanteric fractures who underwent surgical interventions were enrolled in this retrospective cohort study.
Summary · context
Group 1 included patients who were not on any osteoporosis medication prior to fracture and who postoperatively received only calcium and vitamin D; patients in Group 2 were not on any osteoporosis medication prior to fracture, and received teriparatide and calcium and vitamin D postoperatively.
Summary · context
Patients in Group 3 were those who were on alendronate prior to fracture and postfracture received teriparatide as well as calcium and vitamin D.
Report a problemFND-2717567306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

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