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Study · Randomized controlled trial · n = 63 · 2016

4 results

Oxytocin and social context moderate social support seeking in women during negative memory recall.

Cardoso C, Valkanas H, Serravalle L, Ellenbogen MA

Psychoneuroendocrinology3 May 2016Cited by 20 (Europe PMC)

PMID27164224 (opens in a new tab)DOI10.1016/j.psyneuen.2016.05.001 (opens in a new tab)PepBankPUB-27164224
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In participants recalling negative memories without social contact, oxytocin decreased perceived emotional support relative to placebo.

    In plain wordsIn people recalling negative memories alone, oxytocin lowered perceived emotional support compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreasePerceived emotional support during negative memory recall without social contact
    Study

    n = 63

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    During recall of negative memories in the absence of social contact, oxytocin decreased perceived emotional support relative to placebo F(1,62)=10.75, p=0.002.
    1 context sentence
    Summary · context
    Sixty-three individuals (32 female) participated in this randomized, double-blind, placebo-controlled, and within-subject study.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women who were motivated to affiliate with the experimenter, the oxytocin-induced decrease in perceived support without social contact was greater.

    In plain wordsIn women who wanted to connect with the experimenter, oxytocin lowered perceived support more when no social contact was available, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreasePerceived emotional support without social contact in women motivated to affiliate
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this same context, women who were motivated to affiliate with the experimenter following oxytocin administration showed this effect in greater magnitude t(57)=-2.04, p=0.047
    1 context sentence
    Summary · context
    Sixty-three individuals (32 female) participated in this randomized, double-blind, placebo-controlled, and within-subject study.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women who were motivated to affiliate with the experimenter, oxytocin increased perceived support when social contact with the experimenter was available.

    In plain wordsIn women who wanted to connect with the experimenter, oxytocin raised perceived support when social contact was available, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePerceived emotional support with social contact in women motivated to affiliate
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but showed the reverse effect (i.e. increased perceived support in response to oxytocin) when social contact with the experimenter was available t(57)=2.78, p=0.007.
    1 context sentence
    Summary · context
    Sixty-three individuals (32 female) participated in this randomized, double-blind, placebo-controlled, and within-subject study.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In male participants, oxytocin did not show the pattern of changed perceived support seen in women.

    In plain wordsIn men, oxytocin did not show the same pattern of changed perceived support as in women.

    Peptide
    Oxytocin
    Outcome
    No significant changePerceived emotional support in male participants
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Male participants did not evidence this pattern.
    1 context sentence
    Summary · context
    Sixty-three individuals (32 female) participated in this randomized, double-blind, placebo-controlled, and within-subject study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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