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Study · Randomized controlled trial · 2016

5 results

The effects of intranasal oxytocin in opioid-dependent individuals and healthy control subjects: a pilot study.

Woolley JD, Arcuni PA, Stauffer CS, Fulford D, Carson DS, Batki S, Vinogradov S

Psychopharmacology3 May 2016Cited by 38 (Europe PMC)

PMID27137199 (opens in a new tab)PMCIDPMC7452038 (opens in a new tab)DOI10.1007/s00213-016-4308-8 (opens in a new tab)PepBankPUB-27137199
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In opioid-dependent patients receiving opioid replacement therapy, oxytocin was well tolerated.

    In plain wordsIn people on opioid replacement therapy, a single oxytocin dose was well tolerated.

    Peptide
    Oxytocin
    Outcome
    Not applicableTolerability in patients receiving opioid replacement therapy
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Adverse events · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin was well tolerated by patients receiving ORT
    1 context sentence
    Summary · context
    We aimed to assess the tolerability of intranasal oxytocin and its effects on heroin craving, implicit association with heroin and social perceptual ability in opioid-dependent patients receiving opioid replacement therapy (ORT) and healthy control participants.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In opioid-dependent patients receiving opioid replacement therapy, oxytocin had no significant effect on craving.

    In plain wordsIn people on opioid replacement therapy, oxytocin did not significantly change craving.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeroin cue-induced craving
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    but had no significant effects on craving or IAT scores.
    1 context sentence
    Summary · context
    We aimed to assess the tolerability of intranasal oxytocin and its effects on heroin craving, implicit association with heroin and social perceptual ability in opioid-dependent patients receiving opioid replacement therapy (ORT) and healthy control participants.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In opioid-dependent patients receiving opioid replacement therapy, oxytocin had no significant effect on Implicit Association Task scores.

    In plain wordsIn people on opioid replacement therapy, oxytocin did not significantly change implicit association scores.

    Peptide
    Oxytocin
    Outcome
    No significant changeImplicit Association Task score
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    but had no significant effects on craving or IAT scores.
    1 context sentence
    Summary · context
    We aimed to assess the tolerability of intranasal oxytocin and its effects on heroin craving, implicit association with heroin and social perceptual ability in opioid-dependent patients receiving opioid replacement therapy (ORT) and healthy control participants.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In opioid-dependent patients, performance on the Reading the Mind in the Eyes Task was significantly reduced after oxytocin versus placebo, but not in healthy controls.

    In plain wordsIn people on opioid replacement therapy, oxytocin lowered performance on an eye-reading task compared with placebo. This was not seen in healthy controls.

    Peptide
    Oxytocin
    Outcome
    DecreaseRMET performance in opioid-dependent patients
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    There was a significant reduction in RMET performance after oxytocin administration versus placebo in the patient group only
    1 context sentence
    Summary · context
    We aimed to assess the tolerability of intranasal oxytocin and its effects on heroin craving, implicit association with heroin and social perceptual ability in opioid-dependent patients receiving opioid replacement therapy (ORT) and healthy control participants.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In opioid-dependent patients and healthy controls, performance on the Awareness of Social Inference Test was significantly reduced after oxytocin versus placebo.

    In plain wordsIn patients and healthy controls, oxytocin lowered performance on a social inference test compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseTASIT performance in patients and healthy controls
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    and a significant reduction in TASIT performance after oxytocin in both the patient and healthy control groups.
    1 context sentence
    Summary · context
    We aimed to assess the tolerability of intranasal oxytocin and its effects on heroin craving, implicit association with heroin and social perceptual ability in opioid-dependent patients receiving opioid replacement therapy (ORT) and healthy control participants.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT01728909

Methadone Oxytocin Option

University of California, San Franciscon = 64May 2012 to Oct 2014

Substance Abuse · Opioid Dependence · Methadone Treatment

Trial pageClinicalTrials.govUpdated 21 May 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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