In African American youths, OXTR GG individuals exposed to nonsupportive parenting had the shortest telomeres in the control condition and telomeres similar to non at-risk groups in the intervention; A allele carriers showed no difference.
In plain wordsIn African American youths, a gene variant for the oxytocin receptor changed how a family program affected telomere length. No oxytocin was given.
- Peptide
- Oxytocin
- Outcome
- Not applicableTelomere length by OXTR rs53576 genotype, parenting and intervention
- Study
n = 191
- Comparator
- Control condition
- Outcome group
- Aging markers · Aging and longevity
Source sentences
We found a significant three-way interaction between nonsupportive parenting, intervention condition, and OXTR rs53576 genotype.
3 context sentences(design, population, supporting numbers)
OXTR GG individuals, who are suggested to be more sensitive to their social environment, exhibited significantly more variability, evidencing the shortest telomeres when exposed to nonsupportive parenting and randomized to the control condition, and similar telomere lengths to non at-risk groups when randomized to the intervention.
In contrast, those with the A allele showed no statistical difference in telomere lengths across parental and intervention conditions.
We utilized data from African American youths (mean age 17) randomized to intervention (n = 100) or control condition (n = 91) with baseline assessments of genetic status and nonsupportive parenting, and 5-year follow-up assessments of telomere length.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.