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Study · Randomized controlled trial · 2016

2 results

Oxytocin, but not vasopressin, impairs social cognitive ability among individuals with higher levels of social anxiety: a randomized controlled trial.

Tabak BA, Meyer ML, Dutcher JM, Castle E, Irwin MR, Lieberman MD, Eisenberger NI

Social cognitive and affective neuroscience6 Apr 2016Cited by 17 (Europe PMC)

PMID27053769 (opens in a new tab)PMCIDPMC4967803 (opens in a new tab)DOI10.1093/scan/nsw041 (opens in a new tab)PepBankPUB-27053769
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In individuals with higher levels of social anxiety, oxytocin impaired social working memory accuracy compared with placebo.

    In plain wordsIn people with more social anxiety, oxytocin made social working memory accuracy worse than placebo did.

    Peptide
    Oxytocin
    Outcome
    DecreaseSocial working memory accuracy in individuals with higher social anxiety
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT vs placebo impaired social working memory accuracy in participants with higher levels of social anxiety.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo controlled, between-subjects design we investigated whether social anxiety moderated the effects of OT or AVP (vs placebo) on social working memory (i.e. working memory that involves manipulating social information) and non-social working memory.
  2. 02HumanRandomized controlled trialEfficacy outcome

    Oxytocin did not differ from placebo for non-social working memory.

    In plain wordsOxytocin did not change non-social working memory compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeNon-social working memory
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    No differences were found for non-social working memory
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo controlled, between-subjects design we investigated whether social anxiety moderated the effects of OT or AVP (vs placebo) on social working memory (i.e. working memory that involves manipulating social information) and non-social working memory.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT01680718

Neuropeptides and Social Behavior

University of California, Los Angelesn = 160Oct 2012 to Sept 2013

Social Psychology

Trial pageClinicalTrials.govUpdated 28 May 2015

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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