In vitro and in vivo degradation and mechanical properties of ZEK100 magnesium alloy coated with alginate, chitosan and mechano-growth factor.

Gao H, Zhang M, Zhao J, Gao L, Li M

Materials science & engineering. C, Materials for biological applications27 Feb 2016Cited by 17 (Europe PMC)

PMID27040239DOI10.1016/j.msec.2016.02.073PepBankPUB-27040239

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Other
Layer-by-layer coating with alginate, chitosan and MGF inhibited the degradation rate of ZEK100 samples in vitro and in vivo.
In plain wordsIn lab tests and in animals, the coating slowed the breakdown of the metal alloy.
Peptide
MGF / PEG-MGF
Outcome
DecreaseDegradation rate of coated alloy in vitro and in vivo
Study
n: not reported in source
ZEK100 magnesium alloy implant, in vitro and in vivo (femur medullary cavity)
Comparator
Uncoated ZEK100
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
By comparing the degradation of uncoated and multilayer-coated ZEK100 samples in vitro and in vivo, respectively, it is found that the degradation rate of ZEK100 samples can be inhibited by LBL modification on the surface of the sample
1 context sentence(design, population, supporting numbers)
Summary · context
Fabrications of multilayered coatings carrying sodium alginate (ALG), chitosan (CHI) and mechano-growth factor (MGF) on fluoride-pretreated ZEK100 magnesium alloy have been obtained via layer by layer (LBL) to reduce the degradation rate of magnesium alloy in this study.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2704023902
02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Safety outcome
Multilayer-coated ZEK100 magnesium alloy had good biocompatibility based on tissue symptoms in the left femur medullary cavity and material responses on the surface.
In plain wordsIn animals, the coated metal alloy looked well tolerated by the surrounding tissue.
Peptide
MGF / PEG-MGF
Outcome
Not applicableBiocompatibility in femur medullary cavity
Study
n: not reported in source
ZEK100 magnesium alloy implant, in vitro and in vivo (femur medullary cavity)
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In terms of the visible symptom of tissues in the left femur medullary cavity and material responses on the surface, multilayer-coated ZEK100 magnesium alloy has a good biocompatibility.
1 context sentence(design, population, supporting numbers)
Summary · context
Fabrications of multilayered coatings carrying sodium alginate (ALG), chitosan (CHI) and mechano-growth factor (MGF) on fluoride-pretreated ZEK100 magnesium alloy have been obtained via layer by layer (LBL) to reduce the degradation rate of magnesium alloy in this study.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2704023903
03LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Other
Mechanical properties of multilayer-coated ZEK100 samples were almost the same as those of uncoated samples.
In plain wordsIn lab tests, the coated metal alloy had about the same mechanical strength as the uncoated alloy.
Peptide
MGF / PEG-MGF
Outcome
No significant changeMechanical properties of coated versus uncoated alloy
Study
n: not reported in source
ZEK100 magnesium alloy implant, in vitro and in vivo (femur medullary cavity)
Comparator
Uncoated ZEK100
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
the mechanical properties of coated samples are almost the same as those of uncoated samples.
1 context sentence(design, population, supporting numbers)
Summary · context
Fabrications of multilayered coatings carrying sodium alginate (ALG), chitosan (CHI) and mechano-growth factor (MGF) on fluoride-pretreated ZEK100 magnesium alloy have been obtained via layer by layer (LBL) to reduce the degradation rate of magnesium alloy in this study.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2704023901
04LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Other
The fatigue life of multilayer-coated ZEK100 was slightly larger than that of uncoated samples after 1 day of immersion.
In plain wordsIn lab tests, the coated metal alloy had a slightly longer fatigue life than the uncoated alloy after one day of immersion.
Peptide
MGF / PEG-MGF
Outcome
IncreaseFatigue life of coated versus uncoated alloy after 1 day of immersion
Study
n: not reported in source
Comparator
Uncoated ZEK100
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
However, the fatigue life of coated ZEK100 is slightly larger than that of uncoated samples after 1 day of immersion.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2704023904

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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