[EXPERIMENTAL PHARMACOKINETICS AND PHARMACODYNAMICS OF GB-115 DIPEPTIDE ANXIOLYTIC SUBSTANCES].

Kolik LG, Zherdev VP, Boiko SS, Konstantinopol'skii MA, Raskin SY, Gudasheva TA, Mart'yanov VA, Seredenin SB

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2015

PMID27017703PepBankPUB-27017703

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In albino male rats, micronized GB‑115 showed better pharmacokinetic parameters than crystalline GB‑115.
In plain wordsIn rats, micronized GB‑115 showed better pharmacokinetic parameters than crystalline GB‑115.
Peptide
GB-115
Outcome
Direction not reportedPharmacokinetic parameters
Study
ratn: not reported in source
albino male rats
Comparator
Crystalline GB-115
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
In contrast to crystalline, the micronized substance exhibited better pharmacokinetic parameters and higher bioavailability.
1 context sentence(design, population, supporting numbers)
Summary · context
Pharmacokinetics and pharmacological activity of GB-115 dipeptide anxiolytic after oral administration in the form of crystalline and micronized substances was studied in albino male rats.
Report a problemFND-2701770301
02AnimalAnimal study (in vivo)Pharmacokinetics
In albino male rats, micronized GB‑115 had higher bioavailability than crystalline GB‑115.
In plain wordsIn rats, micronized GB‑115 had higher bioavailability than crystalline GB‑115.
Peptide
GB-115
Outcome
IncreaseBioavailability
Study
ratn: not reported in source
albino male rats
Comparator
Crystalline GB-115
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
In contrast to crystalline, the micronized substance exhibited better pharmacokinetic parameters and higher bioavailability.
1 context sentence(design, population, supporting numbers)
Summary · context
Pharmacokinetics and pharmacological activity of GB-115 dipeptide anxiolytic after oral administration in the form of crystalline and micronized substances was studied in albino male rats.
Report a problemFND-2701770302
03AnimalAnimal study (in vivo)Efficacy outcome
In albino male rats, micronized GB‑115 showed pronounced prolonged anxiolytic properties compared with crystalline GB‑115 at the same dose.
In plain wordsIn rats, micronized GB‑115 showed pronounced prolonged anxiety reduction compared with crystalline GB‑115 at the same dose.
Peptide
GB-115
Outcome
IncreaseAnxiolytic properties in elevated plus maze
Study
ratn: not reported in source
albino male rats
Comparator
Crystalline GB-115
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.3 mg/kg · oralAs given in this study (rat).
Source sentences
Summary
In the "elevated plus maze" test, GB-115 in micronized form at a dose 0.3 mg/kg demonstrated pronounced anxiolytic properties during prolonged period as compared to crystalline substance at the same dose.
1 context sentence(design, population, supporting numbers)
Summary · context
Pharmacokinetics and pharmacological activity of GB-115 dipeptide anxiolytic after oral administration in the form of crystalline and micronized substances was studied in albino male rats.
Report a problemFND-2701770303

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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