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Study · Randomized controlled trial · 2016

6 results

Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses.

Zhao W, Yao S, Li Q, Geng Y, Ma X, Luo L, Xu L, Kendrick KM

Human brain mapping26 Mar 2016Cited by 48 (Europe PMC)

PMID27016006 (opens in a new tab)PMCIDPMC6867482 (opens in a new tab)DOI10.1002/hbm.23190 (opens in a new tab)PepBankPUB-27016006
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    Intranasal oxytocin reduced response times for self and other trait judgments compared with placebo.

    In plain wordsOxytocin made people faster at judging traits of themselves and others than placebo did.

    Peptide
    Oxytocin
    Outcome
    DecreaseResponse time for self and other trait judgments
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT reduced response times for making both self and other judgments
    1 context sentence
    Summary · context
    To attempt to distinguish between these two possibilities we performed a double-blind, between-subject, placebo-controlled design study to investigate the effect of intranasal OXT on self and other (mother, classmate, or stranger) trait judgments in conjunction with functional magnetic resonance imaging.
  2. 02HumanRandomized controlled trialEfficacy outcome

    Intranasal oxytocin reduced the accuracy of subsequent recall compared with placebo.

    In plain wordsOxytocin made recall less accurate than placebo did.

    Peptide
    Oxytocin
    Outcome
    DecreaseAccuracy of subsequent recall of trait judgments
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    but also reduced the accuracy of their subsequent recall, thereby abolishing the normal self-bias observed in this task.
    1 context sentence
    Summary · context
    To attempt to distinguish between these two possibilities we performed a double-blind, between-subject, placebo-controlled design study to investigate the effect of intranasal OXT on self and other (mother, classmate, or stranger) trait judgments in conjunction with functional magnetic resonance imaging.
  3. 03HumanRandomized controlled trialEfficacy outcome

    Intranasal oxytocin abolished the normal self-bias in recall observed in the trait judgment task.

    In plain wordsOxytocin removed the usual bias toward remembering things about oneself, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseSelf-bias in recall
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    thereby abolishing the normal self-bias observed in this task.
    1 context sentence
    Summary · context
    To attempt to distinguish between these two possibilities we performed a double-blind, between-subject, placebo-controlled design study to investigate the effect of intranasal OXT on self and other (mother, classmate, or stranger) trait judgments in conjunction with functional magnetic resonance imaging.
  4. 04HumanRandomized controlled trialEfficacy outcome

    Intranasal oxytocin abolished the positive correlation between response and self-esteem scores seen in the placebo group.

    In plain wordsOxytocin removed a link between response and self-esteem scores that was seen with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseCorrelation between response and self-esteem scale scores
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT also abolished the positive correlation between response and self-esteem scale scores seen in the PLC group, suggesting that its effects were strongest in individuals with higher levels of self-esteem.
    1 context sentence
    Summary · context
    To attempt to distinguish between these two possibilities we performed a double-blind, between-subject, placebo-controlled design study to investigate the effect of intranasal OXT on self and other (mother, classmate, or stranger) trait judgments in conjunction with functional magnetic resonance imaging.
  5. 05HumanRandomized controlled trialEfficacy outcome

    Intranasal oxytocin reduced dorsal medial prefrontal cortex responses during self and other trait judgments.

    In plain wordsOxytocin lowered activity in a front brain area during self and other judgments, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseDorsal medial prefrontal cortex response during trait judgments
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    A whole-brain functional magnetic resonance imaging analysis revealed that OXT also reduced responses during both self and other trait judgments in the dorsal (dmPFC) and ventral (vmPFC) medial prefrontal cortex.
    1 context sentence
    Summary · context
    To attempt to distinguish between these two possibilities we performed a double-blind, between-subject, placebo-controlled design study to investigate the effect of intranasal OXT on self and other (mother, classmate, or stranger) trait judgments in conjunction with functional magnetic resonance imaging.
  6. 06HumanRandomized controlled trialEfficacy outcome

    Intranasal oxytocin reduced ventral medial prefrontal cortex responses during self and other trait judgments.

    In plain wordsOxytocin lowered activity in another front brain area during self and other judgments, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseVentral medial prefrontal cortex response during trait judgments
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    A whole-brain functional magnetic resonance imaging analysis revealed that OXT also reduced responses during both self and other trait judgments in the dorsal (dmPFC) and ventral (vmPFC) medial prefrontal cortex.
    1 context sentence
    Summary · context
    To attempt to distinguish between these two possibilities we performed a double-blind, between-subject, placebo-controlled design study to investigate the effect of intranasal OXT on self and other (mother, classmate, or stranger) trait judgments in conjunction with functional magnetic resonance imaging.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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