Intravenous Cosyntropin Versus Epidural Blood Patch for Treatment of Postdural Puncture Headache.

Hanling SR, Lagrew JE, Colmenar DH, Quiko AS, Drastol CA

Pain medicine (Malden, Mass.)1 Jul 2016Cited by 15 (Europe PMC)

PMID27015690DOI10.1093/pm/pnw014PepBankPUB-27015690

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanRandomized controlled trialEfficacy outcome
In patients with postdural puncture headache, pain improved less with cosyntropin than with epidural blood patch at day 1 (P < 0.001).
In plain wordsIn patients with postdural puncture headache, pain improved less with cosyntropin than with epidural blood patch at day 1.
Peptide
Cosyntropin
Outcome
Direction not reportedPain at day 1
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
P
< 0.001
pain, day 1, between treatments
P
< 0.001
pain, day 1, multivariate analysis
Source sentences
Summary
EBP showed significant improvement over cosyntropin at day 1 (P < 0.001) for VRS pain and function scores
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment effects remained at day 1 after multivariate analysis (P < 0.001 and P = 0.002 for pain and function, respectively).
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569001
02HumanRandomized controlled trialEfficacy outcome
In patients with postdural puncture headache, cosyntropin gave worse function than epidural blood patch at day 1.
In plain wordsIn patients with postdural puncture headache, function was worse with cosyntropin than epidural blood patch at day 1.
Peptide
Cosyntropin
Outcome
Direction not reportedFunction at day 1
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
P
< 0.001
function, day 1, between treatments
P
0.002
function, day 1, multivariate analysis
Source sentences
Summary
EBP showed significant improvement over cosyntropin at day 1 (P < 0.001) for VRS pain and function scores
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment effects remained at day 1 after multivariate analysis (P < 0.001 and P = 0.002 for pain and function, respectively).
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569002
03HumanRandomized controlled trialEfficacy outcome
In postdural puncture headache, cosyntropin and epidural blood patch had similar immediate pain efficacy (P = 0.459).
In plain wordsIn postdural puncture headache, cosyntropin and epidural blood patch had similar immediate pain efficacy.
Peptide
Cosyntropin
Outcome
No significant changePain immediately after treatment
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
P
0.459
pain, immediately after treatment, between treatments
Source sentences
Summary
however, cosyntropin demonstrated similar efficacy to EBP immediately after treatment and days 3 and 7 post treatment (respectively, P = 0.459, P = 0.391 and 0.925 for pain and P = 0.189 and 0.478 for function).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569003
04HumanRandomized controlled trialEfficacy outcome
In postdural puncture headache, cosyntropin and epidural blood patch had similar pain efficacy at day 3 (P = 0.391).
In plain wordsIn postdural puncture headache, cosyntropin and epidural blood patch had similar pain efficacy at day 3.
Peptide
Cosyntropin
Outcome
No significant changePain at day 3
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
P
0.391
pain, day 3, between treatments
Source sentences
Summary
however, cosyntropin demonstrated similar efficacy to EBP immediately after treatment and days 3 and 7 post treatment (respectively, P = 0.459, P = 0.391 and 0.925 for pain and P = 0.189 and 0.478 for function).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569004
05HumanRandomized controlled trialEfficacy outcome
In postdural puncture headache, cosyntropin and epidural blood patch had similar pain efficacy at day 7 (P = 0.925).
In plain wordsIn postdural puncture headache, cosyntropin and epidural blood patch had similar pain efficacy at day 7.
Peptide
Cosyntropin
Outcome
No significant changePain at day 7
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
P
0.925
pain, day 7, between treatments
Source sentences
Summary
however, cosyntropin demonstrated similar efficacy to EBP immediately after treatment and days 3 and 7 post treatment (respectively, P = 0.459, P = 0.391 and 0.925 for pain and P = 0.189 and 0.478 for function).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569005
06HumanRandomized controlled trialEfficacy outcome
In postdural puncture headache, cosyntropin and epidural blood patch had similar immediate function efficacy.
In plain wordsIn postdural puncture headache, cosyntropin and epidural blood patch had similar immediate function efficacy.
Peptide
Cosyntropin
Outcome
No significant changeFunction immediately after treatment
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
however, cosyntropin demonstrated similar efficacy to EBP immediately after treatment and days 3 and 7 post treatment (respectively, P = 0.459, P = 0.391 and 0.925 for pain and P = 0.189 and 0.478 for function).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569006
07HumanRandomized controlled trialEfficacy outcome
In postdural puncture headache, cosyntropin and epidural blood patch had similar function efficacy at day 3.
In plain wordsIn postdural puncture headache, cosyntropin and epidural blood patch had similar function efficacy at day 3.
Peptide
Cosyntropin
Outcome
No significant changeFunction at day 3
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
however, cosyntropin demonstrated similar efficacy to EBP immediately after treatment and days 3 and 7 post treatment (respectively, P = 0.459, P = 0.391 and 0.925 for pain and P = 0.189 and 0.478 for function).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569007
08HumanRandomized controlled trialEfficacy outcome
In postdural puncture headache, cosyntropin and epidural blood patch had similar function efficacy at day 7.
In plain wordsIn postdural puncture headache, cosyntropin and epidural blood patch had similar function efficacy at day 7.
Peptide
Cosyntropin
Outcome
No significant changeFunction at day 7
Study
n = 28
Comparator
Epidural blood patch
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
however, cosyntropin demonstrated similar efficacy to EBP immediately after treatment and days 3 and 7 post treatment (respectively, P = 0.459, P = 0.391 and 0.925 for pain and P = 0.189 and 0.478 for function).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-eight patients were randomized to receive EBP or intravenous cosyntropin after diagnosis with post-dural puncture headache.
Report a problemFND-2701569008

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.