[Comparative dynamics of EEG parameters in elderly depressive patients during monotherapy and combined therapy].

Iznak AF, Iznak EV, Kalyn YB, Safarova TP, Sheshenin VS, Gavrilova SI

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2016

PMID26977625DOI10.17116/jnevro20161161147-50PepBankPUB-26977625

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. 2 results from people.

01HumanRandomized controlled trialMechanism
In elderly depressive patients, adding Cerebrolysin to venlafaxine increased EEG spectral power more than antidepressant monotherapy.
In plain wordsIn elderly patients with depression, Cerebrolysin with venlafaxine increased EEG spectral power more than venlafaxine alone.
Peptide
Cerebrolysin
Outcome
IncreaseEEG spectral power
Study
n = 40
Comparator
Venlafaxine alone
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
20.0 ml · intravenous · 4 weeksAs given in this study (human).
Source sentences
Summary
The combined treatment with venlafaxine and cerebrolysin in patients of group 2 led to more pronounced improvement of their brain functional state (seen as an increase of spectral power and normalization of frequency alpha band of parietal-occipital EEG)
4 context sentences(design, population, supporting numbers)
Summary · context
in comparison with patients of group 2 treated by the same antidepressant alone.
Summary · context
To compare the changes in brain functional state in combined antidepressive treatment (venlafaxine plus cerebrolysin) vs. monotherapy with the same antidepressant in elderly depressive patients using quantitative EEG methods.
Summary · context
Forty patients, aged 60-79 years, mean 67.1±5.7) were randomized to two groups.
Summary · context
Patients of group 2 were additionally treated with cerebrolysin (totally 20 i/v infusions during 4 weeks, 20.0 ml in 100 ml isotonic NaCl solution).
Report a problemFND-2697762506
02HumanRandomized controlled trialMechanism
In elderly depressive patients, adding Cerebrolysin to venlafaxine produced greater normalization of parietal-occipital EEG alpha-band frequency than monotherapy.
In plain wordsIn elderly patients with depression, Cerebrolysin with venlafaxine normalized EEG alpha-band frequency more than venlafaxine alone.
Peptide
Cerebrolysin
Outcome
Direction not reportedEEG alpha-band frequency normalization
Study
n = 40
Comparator
Venlafaxine alone
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
20.0 ml · intravenous · 4 weeksAs given in this study (human).
Source sentences
Summary
The combined treatment with venlafaxine and cerebrolysin in patients of group 2 led to more pronounced improvement of their brain functional state (seen as an increase of spectral power and normalization of frequency alpha band of parietal-occipital EEG)
4 context sentences(design, population, supporting numbers)
Summary · context
in comparison with patients of group 2 treated by the same antidepressant alone.
Summary · context
To compare the changes in brain functional state in combined antidepressive treatment (venlafaxine plus cerebrolysin) vs. monotherapy with the same antidepressant in elderly depressive patients using quantitative EEG methods.
Summary · context
Forty patients, aged 60-79 years, mean 67.1±5.7) were randomized to two groups.
Summary · context
Patients of group 2 were additionally treated with cerebrolysin (totally 20 i/v infusions during 4 weeks, 20.0 ml in 100 ml isotonic NaCl solution).
Report a problemFND-2697762507

Studies that did not test the peptide alone4

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

03HumanNot a test of Cerebrolysin aloneRandomized controlled trialEfficacy outcome
In elderly depressive patients, HAMD-17 assessments improved in both groups, including venlafaxine with Cerebrolysin.
In plain wordsIn elderly patients with depression, depression assessments improved in both groups, including venlafaxine with Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseHAMD-17 assessment improvement
Study
n = 40
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
The significant improvement of clinical conditions was shown by the end of the treatment course using both clinical assessments and HAMD-17, CGI-S, CGI-I and MMSE scores in both groups.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare the changes in brain functional state in combined antidepressive treatment (venlafaxine plus cerebrolysin) vs. monotherapy with the same antidepressant in elderly depressive patients using quantitative EEG methods.
Summary · context
Forty patients, aged 60-79 years, mean 67.1±5.7) were randomized to two groups.
Summary · context
Patients of group 2 were additionally treated with cerebrolysin (totally 20 i/v infusions during 4 weeks, 20.0 ml in 100 ml isotonic NaCl solution).
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2697762502
04HumanNot a test of Cerebrolysin aloneRandomized controlled trialEfficacy outcome
In elderly depressive patients, CGI-S assessments improved in both groups, including venlafaxine with Cerebrolysin.
In plain wordsIn elderly patients with depression, illness severity assessments improved in both groups, including venlafaxine with Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseCGI-S assessment improvement
Study
n = 40
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
The significant improvement of clinical conditions was shown by the end of the treatment course using both clinical assessments and HAMD-17, CGI-S, CGI-I and MMSE scores in both groups.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare the changes in brain functional state in combined antidepressive treatment (venlafaxine plus cerebrolysin) vs. monotherapy with the same antidepressant in elderly depressive patients using quantitative EEG methods.
Summary · context
Forty patients, aged 60-79 years, mean 67.1±5.7) were randomized to two groups.
Summary · context
Patients of group 2 were additionally treated with cerebrolysin (totally 20 i/v infusions during 4 weeks, 20.0 ml in 100 ml isotonic NaCl solution).
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2697762503
05HumanNot a test of Cerebrolysin aloneRandomized controlled trialEfficacy outcome
In elderly depressive patients, CGI-I assessments improved in both groups, including venlafaxine with Cerebrolysin.
In plain wordsIn elderly patients with depression, clinical improvement assessments improved in both groups, including venlafaxine with Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseCGI-I assessment improvement
Study
n = 40
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
The significant improvement of clinical conditions was shown by the end of the treatment course using both clinical assessments and HAMD-17, CGI-S, CGI-I and MMSE scores in both groups.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare the changes in brain functional state in combined antidepressive treatment (venlafaxine plus cerebrolysin) vs. monotherapy with the same antidepressant in elderly depressive patients using quantitative EEG methods.
Summary · context
Forty patients, aged 60-79 years, mean 67.1±5.7) were randomized to two groups.
Summary · context
Patients of group 2 were additionally treated with cerebrolysin (totally 20 i/v infusions during 4 weeks, 20.0 ml in 100 ml isotonic NaCl solution).
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2697762504
06HumanNot a test of Cerebrolysin aloneRandomized controlled trialEfficacy outcome
In elderly depressive patients, MMSE assessments improved in both groups, including venlafaxine with Cerebrolysin.
In plain wordsIn elderly patients with depression, cognition assessments improved in both groups, including venlafaxine with Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseMMSE assessment improvement
Study
n = 40
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
The significant improvement of clinical conditions was shown by the end of the treatment course using both clinical assessments and HAMD-17, CGI-S, CGI-I and MMSE scores in both groups.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare the changes in brain functional state in combined antidepressive treatment (venlafaxine plus cerebrolysin) vs. monotherapy with the same antidepressant in elderly depressive patients using quantitative EEG methods.
Summary · context
Forty patients, aged 60-79 years, mean 67.1±5.7) were randomized to two groups.
Summary · context
Patients of group 2 were additionally treated with cerebrolysin (totally 20 i/v infusions during 4 weeks, 20.0 ml in 100 ml isotonic NaCl solution).
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2697762505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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